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[水凝胶敷料Geliperm的实验测试]

[Experimental testing of the hydrogel dressing Geliperm].

作者信息

Staniszewska-Kuś J, Paluch D, Solski L

机构信息

Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów, Wrocławiu.

出版信息

Polim Med. 1988;18(4):197-210.

PMID:3268830
Abstract

The dressing materials used in the local treatment for dressing large defects of skin, subcutaneous and muscular tissues do not have the optimum protective and therapeutic properties. We carry out experiments tending to achieve new kinds of dressing impermeable for microorganisms, free from toxic, allergic, action and acridity and not evoking pathological tissue reaction in a long-lasting contact with the wound. What is more, the new dressing should hasten the cicatrization process of a wound and enable its control as well as soothe the pain if it is possible. Some of these properties were achieved by the usage of cross-linked hydrophilic polymers with high ability of water absorption, creating elastic gels in its presence. The dressing of this type called Geliperm was produced by Geistlich Sons Ltd. and BYK Goldbin-Konstanz firms. The methods of evaluation of hydrogel dressing materials comprising a preliminary, standard and qualifying evaluation were worked out in the Department of Experimental Surgery and Biomaterials Research Medical Academy of Wrocław. According to the worked out scheme of experiments the Geliperm dressing was evaluated. We have discovered on the basis of the carried out experiments that the new generation of gel dressing has, to a large extent, the properties of the so called "ideal dressing".

摘要

用于局部治疗大面积皮肤、皮下组织及肌肉组织缺损的敷料材料并不具备最佳的保护和治疗性能。我们开展了一些实验,旨在研发出新型敷料,使其对微生物具有不透性,无毒、无过敏反应、无刺激性,且在与伤口长期接触时不会引发病理组织反应。此外,新型敷料应能加速伤口的愈合过程,便于对其进行控制,并且在可能的情况下缓解疼痛。通过使用具有高吸水性的交联亲水性聚合物,在其存在下形成弹性凝胶,可实现其中一些性能。这种名为Geliperm的敷料由Geistlich Sons Ltd.和BYK Goldbin-Konstanz公司生产。弗罗茨瓦夫医学院实验外科与生物材料研究部制定了包括初步评估、标准评估和合格评估在内的水凝胶敷料材料评估方法。根据制定的实验方案对Geliperm敷料进行了评估。基于所开展的实验,我们发现新一代凝胶敷料在很大程度上具有所谓“理想敷料”的特性。

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Polim Med. 1988;18(4):197-210.
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