Morreale Massimiliano, Mulè Giuseppe, Ferrante Angelo, D'ignoto Francesco, Cottone Santina
Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), Unit of Renal Disease and Dialysis, European Society of Hypertension Excellence Centre, Università di Palermo, Palermo, Italy
Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), Unit of Renal Disease and Dialysis, European Society of Hypertension Excellence Centre, Università di Palermo, Palermo, Italy.
Angiology. 2016 Aug;67(7):676-82. doi: 10.1177/0003319715613917. Epub 2015 Nov 3.
Connective tissue diseases, like systemic lupus erythematosus (SLE), are associated with early and accelerated atherosclerosis. Recently, the concept of "early vascular aging" (EVA) has been more widely accepted. Aortic stiffness is one of the important markers of EVA. We evaluated EVA and subclinical atherosclerosis, by measuring aortic pulse wave velocity (aPWV) and carotid intima-media thickness (cIMT), in 50 normotensive patients with SLE (mean age: 39 ± 12 years). We compared these participants with 50 age- and sex-matched patients with essential hypertension (EH) and 20 healthy controls. Each participant underwent 24-hour ambulatory blood pressure monitoring (ABPM), aPWV, and cIMT measurements. Clinic and 24-hour ABPM values were significantly lower in patients with SLE and controls when compared with the participants having EH (all P < .0001), but aPWV and cIMT were significantly lower in the control group when compared with patients having SLE and EH (all P < .001). Overall, patients with SLE and EH had similar cIMT and aPWV values (P = .31 and P = .47, respectively). Our results suggest that SLE has a similar deleterious impact on EVA as EH.
结缔组织病，如系统性红斑狼疮（SLE），与早期和加速动脉粥样硬化相关。最近，“早期血管老化”（EVA）的概念已被更广泛接受。主动脉僵硬度是EVA的重要标志物之一。我们通过测量主动脉脉搏波速度（aPWV）和颈动脉内膜中层厚度（cIMT），评估了50例血压正常的SLE患者（平均年龄：39±12岁）的EVA和亚临床动脉粥样硬化。我们将这些参与者与50例年龄和性别匹配的原发性高血压（EH）患者以及20例健康对照进行了比较。每位参与者均接受了24小时动态血压监测（ABPM）、aPWV和cIMT测量。与患有EH的参与者相比，SLE患者和对照组的诊室血压和24小时ABPM值显著更低（所有P<.0001），但与患有SLE和EH的患者相比，对照组的aPWV和cIMT显著更低（所有P<.001）。总体而言，SLE患者和EH患者的cIMT和aPWV值相似（分别为P=.31和P=.47）。我们的结果表明，SLE对EVA的有害影响与EH相似。
