Stokes C L, Cirit M, Lauffenburger D A
Stokes Consulting Redwood City, California, USA.
Department of Biological Engineering, Massachusetts Institute of Technology Cambridge, Massachusetts, USA.
CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):559-62. doi: 10.1002/psp4.12042. Epub 2015 Oct 10.
Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation. This dual approach reduces the need to perfectly rescale and mimic in vivo physiology, an aspiration that is both extremely challenging and not substantively meaningful because of uncertain relevance of any specific physiological condition. Accordingly, this perspective offers a tractable approach for designing interacting MPSs and relating in vitro results to analogous context in vivo.
微生理系统（MPS）或芯片上生理组的缩放可以说是两项相互关联的、基于建模的活动：平台上的缩放和体外-体内转化。这种双重方法减少了对完美重新缩放和模拟体内生理学的需求，由于任何特定生理状况的相关性不确定，这一愿望既极具挑战性又没有实质性意义。因此，这一观点为设计相互作用的MPS并将体外结果与体内类似情况相关联提供了一种可行的方法。
