Zheng Haoquan, Tai Cheuk-Wai, Su Jie, Zou Xiaodong, Gao Feifei
Berzelii Center EXSELENT on Porous Materials and Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, SE-106 91, Sweden.
Dalton Trans. 2015 Dec 14;44(46):20186-92. doi: 10.1039/c5dt03700j.
Mesoporous silica has emerged as one of the most promising carriers for drug delivery systems. However, the synthesis of ultra-small mesoporous silica nanoparticles (UMSNs) and their application in drug delivery remains a significant challenge. Here, spherical UMSNs (∼25 nm) have been synthesized and tested as drug carriers. Anti-cancer drugs mitoxantrone (MX), doxorubicin (DOX) and methotrexate (MTX) have been utilized as model drugs. The pH-responsive drug delivery system can be constructed based on electrostatic interactions between carriers and drug molecules. The UMSNs could store drugs under physiological conditions and release them under acidic conditions. Different pH-responsive release profiles were obtained in phosphate buffer solutions (PBSs) at the designed pH values (from 4.0 to 7.4). MX and DOX can be used in the pH-responsive delivery system, while MTX cannot be used. Furthermore, we found that the physiological stabilities of these drug molecules in UMSNs are in a decreasing order MX > DOX > MTX, which follows the order of their isoelectric point (pI) values.
介孔二氧化硅已成为药物递送系统中最有前景的载体之一。然而，超小介孔二氧化硅纳米颗粒（UMSNs）的合成及其在药物递送中的应用仍然是一项重大挑战。在此，已合成了球形UMSNs（约25纳米）并作为药物载体进行了测试。抗癌药物米托蒽醌（MX）、阿霉素（DOX）和甲氨蝶呤（MTX）已被用作模型药物。基于载体与药物分子之间的静电相互作用，可以构建pH响应型药物递送系统。UMSNs可以在生理条件下储存药物，并在酸性条件下释放药物。在设计的pH值（从4.0到7.4）的磷酸盐缓冲溶液（PBSs）中获得了不同的pH响应释放曲线。MX和DOX可用于pH响应递送系统，而MTX则不能。此外，我们发现这些药物分子在UMSNs中的生理稳定性按MX>DOX>MTX的顺序降低，这与它们的等电点（pI）值顺序一致。
