Liu X L, Liu L D, Zhang S G, Dai S D, Li W Y, Zhang L
Thoracic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Anesthesiology, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
Genet Mol Res. 2015 Oct 28;14(4):13496-503. doi: 10.4238/2015.October.28.10.
We analyzed the expression and clinical significance of δ-catenin in non-small cell lung cancer (NSCLC) and investigated prognosis using human lung cancer samples. Eighty-nine NSCLC patients underwent operation between January and March 2009. There were 53 cases of squamous cell carcinoma, 31 adenocarcinoma, and 5 large cell carcinoma. δ-Catenin in NSCLC patients was detected by immunohistochemistry and analyzed in combination with the clinicopathological characteristics of lung cancer. The relationship between δ-catenin and CD31, D2-40, and vascular endothelial growth factor (VEGF) was compared by immunohistochemistry and the χ(2) test. δ-Catenin appeared in the cytoplasm of adjacent bronchial epithelial cells, indicating negative expression. Positive δ-catenin expression in the cytoplasm of lung cancer tissues was 66.67% (52/78), which was significantly higher than in normal lung tissues. Kaplan-Meier survival analysis suggested that the mean survival time of patients with δ-catenin-positive expression was significantly shorter than in those with negative expression, indicating that positive expression was closely related to poor prognosis of NSCLC. δ-Catenin was highly expressed in NSCLC mainly in the cytoplasm of lung cancer tissues. δ-Catenin-positive expression may be related to poor prognosis of NSCLC. High δ-catenin expression in NSCLC was positively correlated with high CD31 and VEGF expression, but not correlated with D2-40, suggesting that δ-catenin may be related to angiogenesis and not lymphangiogenesis.
我们分析了δ-连环蛋白在非小细胞肺癌（NSCLC）中的表达及临床意义，并利用人肺癌样本研究其预后情况。2009年1月至3月间，89例NSCLC患者接受了手术。其中鳞状细胞癌53例，腺癌31例，大细胞癌5例。采用免疫组织化学法检测NSCLC患者的δ-连环蛋白，并结合肺癌的临床病理特征进行分析。通过免疫组织化学和χ²检验比较δ-连环蛋白与CD31、D2-40及血管内皮生长因子（VEGF）之间的关系。δ-连环蛋白出现在相邻支气管上皮细胞的细胞质中，呈阴性表达。肺癌组织细胞质中δ-连环蛋白阳性表达率为66.67%（52/78），显著高于正常肺组织。Kaplan-Meier生存分析表明，δ-连环蛋白阳性表达患者的平均生存时间显著短于阴性表达患者，提示阳性表达与NSCLC的预后不良密切相关。δ-连环蛋白在NSCLC中主要在肺癌组织细胞质中高表达。δ-连环蛋白阳性表达可能与NSCLC的预后不良有关。NSCLC中δ-连环蛋白高表达与CD31和VEGF高表达呈正相关，但与D2-40无关，提示δ-连环蛋白可能与血管生成有关，而与淋巴管生成无关。
