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[诊断骨质疏松症:2014年美国骨矿研究学会指南中有哪些新内容?]

[Diagnosing osteoporosis: what is new in the 2014 DVO guideline?].

作者信息

Pfeilschifter Johannes

机构信息

MVZ Endokrinologikum Ruhr und Abteilung für Medizinische Informatik, Biometrie und Epidemiologie, Ruhr-Universität Bochum.

出版信息

Dtsch Med Wochenschr. 2015 Nov;140(22):1667-71. doi: 10.1055/s-0041-103417. Epub 2015 Nov 4.

Abstract

Suitable diagnostic strategies beyond general measures of fracture prevention which allow the identification of those individuals who are likely to benefit most from medical treatment are of utmost importance for an efficient treatment of osteoporosis. Since 2003 the "Dachverband Osteologie" (DVO) provides recommendations for the diagnostics and treatment of osteoporosis in German speaking regions. The most recent update was in November 2014. The DVO guideline provides detailed recommendations for a diagnostic examination depending on age, gender, and the presence and strength of clinical risk factors. The number of clinical fractures risks on which the diagnostic and therapeutic recommendations of the DVO guideline 2014 are based has increased in comparison to the DVO guideline 2009. In addition to the fracture risks listed in the previous version of the DVO guideline the list now also includes monoclonal gammopathy of unknown significance, ankylosing spondylitis, COPD, heart failure, celiac disease, type 2 diabetes mellitus, long-term treatment with proton pump inhibitors and a treatment with high-dose inhaled glucocorticoids. For all persons with an increased fracture risk the guideline recommends a diagnostic workup, comprising medical history, clinical examination including assessment of fall risk, DXA measurements at the lumbar spine, proximal total femur and femoral neck, blood analysis and, if indicated, appropriate imaging procedures. The trabecular bone score offers a new diagnostic option for fracture prediction.

摘要

除了骨折预防的一般措施外,合适的诊断策略对于有效治疗骨质疏松症至关重要,这些策略能够识别出那些可能从药物治疗中获益最大的个体。自2003年以来,“德国骨科学会”(DVO)为德语区骨质疏松症的诊断和治疗提供建议。最近一次更新是在2014年11月。DVO指南根据年龄、性别以及临床风险因素的存在与否和强度,为诊断检查提供了详细建议。与2009年的DVO指南相比,2014年DVO指南的诊断和治疗建议所依据的临床骨折风险数量有所增加。除了DVO指南先前版本中列出的骨折风险外,现在的列表还包括意义未明的单克隆丙种球蛋白病、强直性脊柱炎、慢性阻塞性肺疾病、心力衰竭、乳糜泻、2型糖尿病、质子泵抑制剂长期治疗以及高剂量吸入糖皮质激素治疗。对于所有骨折风险增加的人,该指南建议进行诊断性检查,包括病史采集、临床检查(包括跌倒风险评估)、腰椎、近端全股骨和股骨颈的双能X线吸收测定、血液分析以及必要时进行适当的影像学检查。小梁骨评分提供了一种新的骨折预测诊断选择。

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