四丁基铵硫氢化物为硫化氢和阴离子结合研究提供了一种可溶于有机溶液的硫氢根离子（HS⁻）的便捷来源。
NBu4SH provides a convenient source of HS(-) soluble in organic solution for H2S and anion-binding research.
作者信息
Hartle Matthew D, Meininger Daniel J, Zakharov Lev N, Tonzetich Zachary J, Pluth Michael D
机构信息
Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, 1253 University of Oregon, Eugene, Oregon 97403-1253, USA.
Department of Chemistry, University of Texas at San Antonio (UTSA), San Antonio, TX 78249, USA.
出版信息
Dalton Trans. 2015 Dec 14;44(46):19782-5. doi: 10.1039/c5dt03355a.
Hydrogen sulfide (H2S) has gained significant interest within the scientific community due to its expanding roles in different (patho)physiological processes. Despite this importance, the chemical mechanisms by which H2S exerts its action remain under-scrutinized. Biomimetic investigations in organic solution offer the potential to clarify these mechanisms and to delineate the differential reactivity between H2S and HS(-). However, such studies are hampered by the lack of readily-available sources of HS(-) that are soluble in organic solution. Here we present a simple method for preparing analytically pure tetrabutylammonium hydrosulfide (NBu4SH), which we anticipate will be of significant utility to researchers in the H2S and anion-binding communities.
由于硫化氢（H₂S）在不同的（病理）生理过程中发挥着越来越广泛的作用，它在科学界引起了极大的关注。尽管其具有重要性，但H₂S发挥作用的化学机制仍未得到充分研究。在有机溶液中进行的仿生研究有潜力阐明这些机制，并描绘出H₂S与HS⁻之间的差异反应性。然而，此类研究因缺乏可溶于有机溶液的现成HS⁻来源而受到阻碍。在此，我们提出一种制备分析纯四丁基硫化铵（NBu₄SH）的简单方法，我们预计这将对H₂S和阴离子结合领域的研究人员具有重要用途。
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