Ribeiro Jeany Borges e Silva, Diógenes Esther Cristina Arruda Oliveira, Bezerra Patrícia Carvalho, Coutinho Tanila Aguiar Andrade, de Almeida Cícera Geórgia Félix, e Souza Miguel Ângelo Nobre
Laboratório de Gastroenterologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Arq Bras Cir Dig. 2015 Jul-Sep;28(3):174-7. doi: 10.1590/S0102-67202015000300007.
Through rhythmic variations, the diaphragm influence lower esophageal sphincter (LES) pressure acting as an external sphincter. LES pressure recording is characterized by increased pressure in inspiration due to contraction of the diaphragmatic crura that involves the sphincter.
To describe a method of measuring LES pressure during standardized inspiratory maneuvers with increasing loads.
The study population comprised of eight healthy female volunteers (average age of 31.5 years). An esophageal high-resolution manometry and impedance system was used for measuring the LES pressure during 3-second inspiratory efforts under 12, 24 and 48 cm H2O loads (Threshold maneuvers).
There was a significant difference between the average maximum LES pressure and the average maximum basal LES pressure during the first (76.19±17.92 difference, p=0.0008), second (86.92±19.01 difference, p=0.0004), and third seconds of the maneuver (90.86±17.93 difference, p=0.0002), with 12, 24 and 48 cmH2O loads.
This maneuver is a standardization of the inspiratory LES pressure and may better differentiate patients with reflux disease from healthy individuals, and may also be useful for monitoring the treatment of these patients through inspiratory muscle training.
通过节律变化，膈肌作为外部括约肌影响下食管括约肌（LES）压力。LES压力记录的特点是吸气时由于涉及括约肌的膈脚收缩而压力增加。
描述一种在负荷增加的标准化吸气动作期间测量LES压力的方法。
研究人群包括8名健康女性志愿者（平均年龄31.5岁）。使用食管高分辨率测压和阻抗系统在12、24和48 cm H2O负荷（阈值动作）下3秒吸气动作期间测量LES压力。
在动作的第一秒（差异为76.19±17.92，p = 0.0008）、第二秒（差异为86.92±19.01，p = 0.0004）和第三秒（差异为90.86±17.93，p = 0.0002），12、24和48 cmH2O负荷下，平均最大LES压力与平均最大基础LES压力之间存在显著差异。
该动作是吸气性LES压力的标准化，可能更好地区分反流性疾病患者与健康个体，也可能有助于通过吸气肌训练监测这些患者的治疗。
