McClelland Jessica, Kekic Maria, Campbell Iain C, Schmidt Ulrike
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Eur Eat Disord Rev. 2016 Mar;24(2):157-63. doi: 10.1002/erv.2414. Epub 2015 Nov 4.
This case series examined the therapeutic potential of repetitive transcranial magnetic stimulation in five women with enduring anorexia nervosa.
Participants received ~20 sessions of neuronavigated high-frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex. Body mass index, eating disorder (ED) symptoms and mood were assessed pre-treatment and post-treatment, at 6-month and 12-month follow-up (FU). Qualitative feedback regarding the intervention was obtained from participants and carers.
From pre-treatment to post-treatment, ED and affective symptoms improved significantly, and body mass index remained stable. Further improvements in ED symptoms/mood were seen at 6-month FU with 3/5 and 2/5 participants deemed 'recovered' on the Eating Disorders Examination Questionnaire and Depression, Anxiety and Stress Scale, respectively. However, most participants had lost some weight, and therapeutic effects on psychopathology had waned by 12-month FU. Qualitative feedback regarding the intervention was encouraging.
Repetitive transcranial magnetic stimulation was well tolerated, and preliminary evidence is provided for its therapeutic potential in anorexia nervosa.
本病例系列研究了重复经颅磁刺激对五名患有持续性神经性厌食症女性的治疗潜力。
参与者接受了约20次经神经导航的高频重复经颅磁刺激，刺激部位为左侧背外侧前额叶皮层。在治疗前、治疗后、6个月和12个月随访时评估体重指数、饮食失调（ED）症状和情绪。从参与者和护理人员处获得了关于该干预措施的定性反馈。
从治疗前到治疗后，饮食失调和情感症状显著改善，体重指数保持稳定。在6个月随访时，饮食失调症状/情绪进一步改善，分别有3/5和2/5的参与者在饮食失调检查表和抑郁、焦虑和压力量表上被认为“康复”。然而，大多数参与者体重有所减轻，到12个月随访时，对精神病理学的治疗效果已经减弱。关于该干预措施的定性反馈令人鼓舞。
重复经颅磁刺激耐受性良好，并为其在神经性厌食症中的治疗潜力提供了初步证据。
