Weber Christine, Gottschaldt Michael, Hoogenboom Richard, Schubert Ulrich S
Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743, Jena, Germany.
Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
Methods Mol Biol. 2016;1367:49-59. doi: 10.1007/978-1-4939-3130-9_5.
The advancement in the field of living and controlled polymerization techniques provides the opportunity for careful bottom-up design of polymers for biomedical applications according to their specific needs. This contribution describes the detailed methodology to functionalize poly(2-ethyl-2-oxazoline), a polymer with properties very similar to polyethylene glycol, in a stereo-selective manner with a range of carbohydrates that can serve as biological targeting units. The obtained building blocks can subsequently be applied for the synthesis of more complex polymeric architectures.
活性及可控聚合技术领域的进展为根据生物医学应用的特定需求，自下而上精心设计聚合物提供了契机。本论文介绍了一种详细的方法，该方法能够以立体选择性的方式，用一系列可作为生物靶向单元的碳水化合物对聚（2-乙基-2-恶唑啉）进行功能化，聚（2-乙基-2-恶唑啉）是一种性质与聚乙二醇非常相似的聚合物。随后，所获得的结构单元可用于合成更复杂的聚合物结构。
