Filer L J, Stegink L D
Department of Pediatrics, College of Medicine, University of Iowa, Iowa City 52242.
Diabetes Care. 1989 Jan;12(1):67-74. doi: 10.2337/diacare.12.1.67.
This study reviews clinical studies testing the effects of various doses of aspartame on blood levels of phenylalanine, aspartate, and methanol in normal subjects and known phenylketonuric heterozygotes. The effect of aspartame on the phenylalanine-to-large neutral amino acid ratio under various feeding situations is shown. The clinical studies of aspartame in diabetic subjects are limited to observations of its effects on blood levels of glucose, lipids, insulin, and glucagon. These studies clearly demonstrate the safety of this high-intensity sweetener for use by humans.
本研究回顾了多项临床研究，这些研究测试了不同剂量的阿斯巴甜对正常受试者以及已知苯丙酮尿症杂合子体内苯丙氨酸、天冬氨酸和甲醇血液水平的影响。展示了阿斯巴甜在不同喂养情况下对苯丙氨酸与大中性氨基酸比例的影响。关于阿斯巴甜在糖尿病患者中的临床研究仅限于观察其对血糖、血脂、胰岛素和胰高血糖素血液水平的影响。这些研究清楚地证明了这种高强度甜味剂供人类使用的安全性。
