Perry Anamarija M, Diebold Jacques, Nathwani Bharat N, MacLennan Kenneth A, Müller-Hermelink Hans K, Bast Martin, Boilesen Eugene, Armitage James O, Weisenburger Dennis D
Department of Pathology, University of Manitoba, 820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.
Department of Anatomic Pathology and Cytology, Hotel-Dieu, University Denis Diderot, 75181 Paris Cedex 04, Paris, France.
Ann Hematol. 2016 Jan;95(2):245-51. doi: 10.1007/s00277-015-2543-4. Epub 2015 Nov 5.
Large and systematic studies of non-Hodgkin lymphoma (NHL) in the Far East (FE) with good comparative data are scarce in the literature. In this study, five expert hematopathologists classified 730 consecutive cases of newly-diagnosed NHL from four sites in the FE (excluding Japan) using the World Health Organization classification. The results were compared to 399 cases from North America (NA). We found a significantly higher male to female ratio in the FE compared to NA (1.7 versus 1.1; p < 0.05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in the FE (58 and 51 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). The FE had a significantly lower relative frequency of B-NHL and a higher frequency of T-NHL (82 vs. 18 %) compared to NA (90.5 vs. 9.5 %). Among mature B cell lymphomas, the FE had a significantly higher relative frequency of HG B-NHL (54.8 %) and a lower frequency of LG B-NHL (27.2 %) than NA (34.3 and 56.1 %, respectively). Diffuse large B cell lymphoma was more common in the FE (49.4 %) compared to NA (29.3 %), whereas the relative frequency of follicular lymphoma was lower in the FE (9.4 %) compared to NA (33.6 %). Among T-NHL, nasal NK/T cell NHL was more frequent in the FE (5.2 %) compared to NA (0 %). Peripheral T cell lymphoma was also more common in the FE (9.1 %) than in NA (5.3 %). Further epidemiologic studies are needed to better understand the pathobiology of these differences.
在文献中，针对远东地区（FE，不包括日本）进行的大规模系统性非霍奇金淋巴瘤（NHL）研究以及具有良好对比数据的研究较为匮乏。在本研究中，五位血液病理学专家依据世界卫生组织分类标准，对来自远东地区（不包括日本）四个地点的730例新诊断NHL连续病例进行了分类。研究结果与来自北美的399例病例进行了对比。我们发现，与北美相比，远东地区的男女比例显著更高（分别为1.7和1.1；p < 0.05）。远东地区低级别（LG）和高级别（HG）B-NHL患者的中位年龄（分别为58岁和51岁）显著低于北美（分别为64岁和68岁）。与北美（90.5%对9.5%）相比，远东地区B-NHL的相对频率显著更低，T-NHL的频率更高（82%对18%）。在成熟B细胞淋巴瘤中，与北美（分别为34.3%和56.1%）相比，远东地区HG B-NHL的相对频率显著更高（54.8%），LG B-NHL的频率更低（27.2%）。与北美（29.3%）相比，弥漫性大B细胞淋巴瘤在远东地区更为常见（49.4%），而与北美（33.6%）相比，滤泡性淋巴瘤在远东地区的相对频率更低（9.4%）。在T-NHL中，与北美（0%）相比，鼻型NK/T细胞NHL在远东地区更为常见（5.2%）。外周T细胞淋巴瘤在远东地区（9.1%）也比北美（5.3%）更为常见。需要进一步开展流行病学研究，以更好地了解这些差异的病理生物学机制。
