脑膜瘤中表观扩散系数与Ki-67增殖指数的关系。
Relation of apparent diffusion coefficient with Ki-67 proliferation index in meningiomas.
作者信息
Baskan Ozdil, Silav Gokalp, Bolukbasi Fatih Han, Canoz Ozlem, Geyik Serdar, Elmaci Ilhan
机构信息
1 Department of Radiology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
2 Department of Neurosurgery, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
出版信息
Br J Radiol. 2016;89(1057):20140842. doi: 10.1259/bjr.20140842. Epub 2015 Nov 5.
OBJECTIVE
The purpose of this study was to investigate the relationship between Ki-67 proliferation indexes and apparent diffusion coefficient (ADC) values of low-grade and atypical/anaplastic (high-grade) meningiomas.
METHODS
Pre-operative diffusion-weighted imaging and histopathological evaluation of 44 patients with meningiomas were performed retrospectively. Regions of interest (ROIs) were manually drawn on the ADC images. In total six ROI measurements were taken in three consecutive slices, and the average of the mean ADC value was used. The relationship between the ADC and Ki-67 values was investigated, and the ADC values of the low-grade and high-grade meningiomas were compared.
RESULTS
31 (70%) patients had low-grade the meningiomas. 10 (23%) patients had atypical and 3 (7%) had anaplastic meningiomas. ADC values of the low-grade and high-grade meningiomas were 0.81 ± 0.12 × 10(-3) and 0.66 ± 0.08 × 10(-3) mm(2) s(-1), respectively. Ki-67 proliferation indexes were 2.19% ± 1.14% for low-grade and 11.20% ± 9.80% for high-grade meningiomas. A statistically significant negative correlation between Ki-67 proliferation index and ADC values of the low-grade and high-grade meningiomas was detected (r(2) = 0.326, p < 0.001). High-grade meningiomas had lower ADC values than that of low-grade meningiomas. There was statistically significant difference between the ADC values of the low-grade and high-grade meningiomas (p < 0.001).
CONCLUSION
Our data provide an inverse correlation between the ADC and Ki-67 proliferation index values of meningiomas. ADC values can be used for histopathological characterization of the meningiomas and pre-surgical planning.
ADVANCES IN KNOWLEDGE
The purpose of this study was to investigate the relationship between Ki-67 proliferation indexes and ADC values of low-grade and atypical/anaplastic (high-grade) meningiomas. In addition, we compared the ADC and Ki-67 proliferative index values of the low-grade and atypical/anaplastic (high-grade) meningiomas. We concluded that there was an inverse correlation between the ADC and Ki-67 proliferation index values in meningiomas, and we have found statistically significant difference between the ADC values of the low-grade and high-grade meningiomas. ADC values can be used for histopathological characterization of the meningiomas and pre-surgical planning.
目的
本研究旨在探讨低级别及非典型/间变性（高级别）脑膜瘤的Ki-67增殖指数与表观扩散系数（ADC）值之间的关系。
方法
回顾性分析44例脑膜瘤患者的术前扩散加权成像和组织病理学评估结果。在ADC图像上手动绘制感兴趣区域（ROI）。在连续三个切片上共进行六次ROI测量，并采用平均ADC值的平均值。研究ADC值与Ki-67值之间的关系，并比较低级别和高级别脑膜瘤的ADC值。
结果
31例（70%）患者为低级别脑膜瘤。10例（23%）患者为非典型脑膜瘤，3例（7%）为间变性脑膜瘤。低级别和高级别脑膜瘤的ADC值分别为0.81±0.12×10⁻³和0.66±0.08×10⁻³mm²/s。低级别脑膜瘤的Ki-67增殖指数为2.19%±1.14%，高级别脑膜瘤为11.20%±9.80%。检测到低级别和高级别脑膜瘤的Ki-67增殖指数与ADC值之间存在统计学显著的负相关（r² = 0.326，p < 0.001）。高级别脑膜瘤的ADC值低于低级别脑膜瘤。低级别和高级别脑膜瘤的ADC值之间存在统计学显著差异（p < 0.001）。
结论
我们的数据表明脑膜瘤的ADC值与Ki-67增殖指数之间呈负相关。ADC值可用于脑膜瘤的组织病理学特征分析和术前规划。
知识进展
本研究旨在探讨低级别及非典型/间变性（高级别）脑膜瘤的Ki-67增殖指数与ADC值之间的关系。此外，我们比较了低级别和非典型/间变性（高级别）脑膜瘤的ADC值与Ki-67增殖指数值。我们得出结论，脑膜瘤的ADC值与Ki-67增殖指数之间呈负相关，并且我们发现低级别和高级别脑膜瘤的ADC值之间存在统计学显著差异。ADC值可用于脑膜瘤的组织病理学特征分析和术前规划。
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