扩散加权磁共振成像作为胶质瘤治疗反应的生物标志物
Diffusion-weighted MRI as a biomarker for treatment response in glioma.
作者信息
Schmainda Kathleen M
出版信息
CNS Oncol. 2012 Nov;1(2):169-80. doi: 10.2217/cns.12.25.
Abstract
Diffusion-weighted imaging (DWI) is a powerful MRI method, which probes abnormalities of tissue structure by detecting microscopic changes in water mobility at a cellular level beyond what is available with other imaging techniques. Accordingly, DWI has the potential to identify pathology before gross anatomic changes are evident on standard anatomical brain images. These features of tissue characterization and earlier detection are what make DWI particularly appealing for the evaluation of gliomas and the newer therapies where standard anatomical imaging is proving insufficient. This article focuses on the basic principles and applications of DWI, and its derived parameter, the apparent diffusion coefficient, for the purposes of diagnosis and evaluation of glioma, especially in the context of monitoring response to therapy.
摘要
扩散加权成像（DWI）是一种强大的磁共振成像（MRI）方法，它通过检测细胞水平上水分子运动的微观变化来探测组织结构异常，这是其他成像技术所无法做到的。因此，在标准解剖学脑图像上明显的大体解剖学变化出现之前，DWI有潜力识别病变。组织特征化和早期检测的这些特性使得DWI在评估胶质瘤以及标准解剖学成像已证明不足的新型治疗方法中特别具有吸引力。本文重点介绍DWI及其衍生参数表观扩散系数的基本原理和应用，用于胶质瘤的诊断和评估，特别是在监测治疗反应的背景下。
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