Tsai Yueh-Ting, Hung Kuo-Chuan, Shih Yun-Ju, Lim Sher-Wei, Yang Cheng-Chun, Kuo Yu-Ting, Chen Jeon-Hor, Ko Ching-Chung
Department of Medical Imaging, Chi Mei Medical Center, Tainan 710, Taiwan.
Department of Anesthesiology, Chi Mei Medical Center, Tainan 710, Taiwan.
Diagnostics (Basel). 2022 Mar 4;12(3):630. doi: 10.3390/diagnostics12030630.
The meta-analysis aimed to compare the preoperative apparent diffusion coefficient (ADC) values between low-grade meningiomas (LGMs) and high-grade meningiomas (HGMs). Medline, Cochrane, Scopus, and Embase databases were screened up to January 2022 for studies investigating the ADC values of meningiomas. The study endpoint was the reported ADC values for LGMs and HGMs. Further subgroup analyses between 1.5T and 3T MRI scanners, ADC threshold values, ADC in different histological LGMs, and correlation coefficients (r) between ADC and Ki-67 were also performed. The quality of studies was evaluated by the quality assessment of diagnostic accuracy studies (QUADAS-2). A χ2-based test of homogeneity was performed using Cochran’s Q statistic and inconsistency index (I2). Twenty-five studies with a total of 1552 meningiomas (1102 LGMs and 450 HGMs) were included. The mean ADC values (×10−3 mm2/s) were 0.92 and 0.79 for LGMs and HGMs, respectively. Compared with LGMs, significantly lower mean ADC values for HGMs were observed with a pooled difference of 0.13 (p < 0.00001). The results were consistent in both 1.5T and 3T MRI scanners. For ADC threshold values, pooled sensitivity of 69%, specificity of 82%, and AUC of 0.84 are obtained for differentiation between LGMs and HGMs. The mean ADC (×10−3 mm2/s) in different histological LGMs ranged from 0.87 to 1.22. Correlation coefficients (r) of mean ADC and Ki-67 ranged from −0.29 to −0.61. Preoperative ADC values are a useful tool for differentiating between LGMs and HGMs. Results of this study provide valuable information for planning treatments in meningiomas.
这项荟萃分析旨在比较低级别脑膜瘤（LGMs）和高级别脑膜瘤（HGMs）术前的表观扩散系数（ADC）值。截至2022年1月，对Medline、Cochrane、Scopus和Embase数据库进行了筛选，以查找研究脑膜瘤ADC值的研究。研究终点是报告的LGMs和HGMs的ADC值。还对1.5T和3T MRI扫描仪之间、ADC阈值、不同组织学类型LGMs中的ADC以及ADC与Ki-67之间的相关系数（r）进行了进一步的亚组分析。通过诊断准确性研究的质量评估（QUADAS-2）对研究质量进行了评估。使用 Cochr an's Q统计量和不一致指数（I2）进行了基于χ2的同质性检验。纳入了25项研究，共1552例脑膜瘤（1102例LGMs和450例HGMs）。LGMs和HGMs的平均ADC值（×10−3 mm2/s）分别为0.92和0.79。与LGMs相比，HGMs的平均ADC值显著更低，合并差异为0.13（p < 0.00001）。在1.5T和3T MRI扫描仪中的结果均一致。对于ADC阈值，区分LGMs和HGMs的合并敏感性为69%，特异性为82%，曲线下面积（AUC）为0.84。不同组织学类型LGMs中的平均ADC（×10−3 mm2/s）范围为0.87至1.22。平均ADC与Ki-67的相关系数（r）范围为−0.29至−0.61。术前ADC值是区分LGMs和HGMs的有用工具。本研究结果为脑膜瘤的治疗规划提供了有价值的信息。
