Shen Hongliang, Yang Peiqian, Liu Qingjun, Tian Ye
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
J Int Med Res. 2015 Dec;43(6):747-57. doi: 10.1177/0300060515587576. Epub 2015 Nov 3.
To explore expression and clinical relevance of phosphohistidine phosphatase 1 (PHPT1) in clear-cell renal cell carcinoma.
Patients with clear-cell renal cell carcinoma who underwent radical or nephron-sparing nephrectomy were enrolled. Correlations between PHPT1 expression and demographic and clinical characteristics were analysed prospectively.
In total, 122 patients (78 male/44 female) were included. In normal kidney tissue, PHPT1 expression was observed only in the proximal tubule. High PHPT1 expression levels were associated with larger tumour size, higher Fuhrman nuclear grade and advanced pathological tumour-node-metastasis (pTNM) stage compared with low PHPT1 expression levels. Patients with low PHPT1 expression showed better overall survival and progression-free survival compared with those with high PHPT1 expression. In addition, multivariate analysis showed that nuclear grade and pTNM stage were independent predictors of progression-free survival and overall survival in patients with clear-cell renal cell carcinoma. PHPT1 expression was also an independent predictor of overall survival but not progression-free survival.
PHPT1 was expressed in the epithelium of proximal tubuli and nuclei of clear-cell renal cell carcinoma tissue samples. High levels of 14 kDa phosphohistidine phosphatase protein were negatively associated with overall survival and progression-free survival in patients with clear-cell renal cell carcinoma.
探讨磷酸组氨酸磷酸酶1（PHPT1）在透明细胞肾细胞癌中的表达及其临床相关性。
纳入接受根治性或保留肾单位肾切除术的透明细胞肾细胞癌患者。前瞻性分析PHPT1表达与人口统计学和临床特征之间的相关性。
共纳入122例患者（78例男性/44例女性）。在正常肾组织中，仅在近端小管中观察到PHPT1表达。与低PHPT1表达水平相比，高PHPT1表达水平与更大的肿瘤大小、更高的Fuhrman核分级和更高的病理肿瘤-淋巴结-转移（pTNM）分期相关。与高PHPT1表达的患者相比，低PHPT1表达的患者总体生存率和无进展生存率更高。此外，多因素分析显示，核分级和pTNM分期是透明细胞肾细胞癌患者无进展生存率和总体生存率的独立预测因素。PHPT1表达也是总体生存率的独立预测因素，但不是无进展生存率的独立预测因素。
PHPT1在透明细胞肾细胞癌组织样本的近端小管上皮和细胞核中表达。高水平的14 kDa磷酸组氨酸磷酸酶蛋白与透明细胞肾细胞癌患者的总体生存率和无进展生存率呈负相关。
