Lee R G
Department of Clinical Neurosciences, University of Calgary, Canada.
Eur Neurol. 1989;29 Suppl 1:13-8. doi: 10.1159/000116448.
Although rigidity and akinesia are two of the cardinal features of Parkinson's disease, their exact pathophysiology remains uncertain. Mechanisms which may contribute to rigidity include accentuation of the long-latency component of the stretch reflex and enhanced fusimotor drive causing increased sensitivity of muscle spindles. Current evidence concerning the role of these factors in rigidity is reviewed. The relationship between akinesia, prolonged reaction times, and delay in initiation of internally generated movements in parkinsonian patients is discussed.
尽管僵硬和运动不能是帕金森病的两个主要特征，但其确切的病理生理学仍不明确。可能导致僵硬的机制包括牵张反射长潜伏期成分的增强以及运动神经驱动增强导致肌梭敏感性增加。本文综述了关于这些因素在僵硬中作用的现有证据。还讨论了帕金森病患者运动不能、反应时间延长与自发运动起始延迟之间的关系。
