York Timothy, Powell Samuel B, Gao Shengkui, Kahan Lindsey, Charanya Tauseef, Saha Debajit, Roberts Nicholas W, Cronin Thomas W, Marshall Justin, Achilefu Samuel, Lake Spencer P, Raman Baranidharan, Gruev Viktor
Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, MO 63130 USA (
Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO 63130 USA (
Proc IEEE Inst Electr Electron Eng. 2014 Oct;102(10):1450-1469. doi: 10.1109/JPROC.2014.2342537. Epub 2014 Aug 20.
In this paper, we present recent work on bioinspired polarization imaging sensors and their applications in biomedicine. In particular, we focus on three different aspects of these sensors. First, we describe the electro-optical challenges in realizing a bioinspired polarization imager, and in particular, we provide a detailed description of a recent low-power complementary metal-oxide-semiconductor (CMOS) polarization imager. Second, we focus on signal processing algorithms tailored for this new class of bioinspired polarization imaging sensors, such as calibration and interpolation. Third, the emergence of these sensors has enabled rapid progress in characterizing polarization signals and environmental parameters in nature, as well as several biomedical areas, such as label-free optical neural recording, dynamic tissue strength analysis, and early diagnosis of flat cancerous lesions in a murine colorectal tumor model. We highlight results obtained from these three areas and discuss future applications for these sensors.
在本文中，我们展示了关于生物启发式偏振成像传感器及其在生物医学中应用的近期工作。特别地，我们聚焦于这些传感器的三个不同方面。首先，我们描述了实现生物启发式偏振成像仪时的电光挑战，尤其是详细介绍了一种近期的低功耗互补金属氧化物半导体（CMOS）偏振成像仪。其次，我们专注于为这类新型生物启发式偏振成像传感器量身定制的信号处理算法，例如校准和插值。第三，这些传感器的出现使得在表征自然界中的偏振信号和环境参数以及多个生物医学领域取得了快速进展，如无标记光学神经记录、动态组织强度分析以及小鼠结直肠癌模型中扁平癌性病变的早期诊断。我们突出了从这三个领域获得的结果，并讨论了这些传感器的未来应用。
