Raylman Raymond R, Vaigneur Keith, Stolin Alexander V, Jaliparthi Gangadhar
Center for Advanced Imaging, Department of Radiology, West Virginia University, Morgantown, WV 26508 USA.
President of Agile Technologies, Knoxville, TN 37932 USA.
IEEE Trans Nucl Sci. 2015 Jun;62(3):694-698. doi: 10.1109/TNS.2015.2392085. Epub 2015 Feb 19.
Metabolic imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. Our group has previously developed a high-resolution positron emission tomography imaging and biopsy device (PEM-PET) to detect and guide the biopsy of suspicious breast lesions. Initial testing revealed that the imaging field-of-view (FOV) of the scanner was smaller than the physical size of the detector's active area, which could hinder sampling of breast areas close to the chest wall. The purpose of this work was to utilize segmented, tapered light guides for optically coupling the scintillator arrays to arrays of position-sensitive photomultipliers to increase both the active FOV and identification of individual scintillator elements. Testing of the new system revealed that the optics of these structures made it possible to discern detector elements from the complete active area of the detector face. In the previous system the top and bottom rows and left and right columns were not identifiable. Additionally, use of the new light guides increased the contrast of individual detector elements by up to 129%. Improved element identification led to a spatial resolution increase by approximately 12%. Due to attenuation of light in the light guides the detector energy resolution decreased from 18.5% to 19.1%. Overall, these improvements should increase the field-of-view and spatial resolution of the dedicated breast-PET system.
代谢成像技术有可能改善对乳腺致密和/或纤维囊性变女性癌症的检测和诊断。我们的团队此前开发了一种高分辨率正电子发射断层成像与活检设备(PEM-PET),用于检测和引导对可疑乳腺病变的活检。初步测试显示,该扫描仪的成像视野(FOV)小于探测器有效区域的物理尺寸,这可能会妨碍对靠近胸壁的乳腺区域进行采样。这项工作的目的是利用分段的锥形光导将闪烁体阵列与位置灵敏光电倍增管阵列进行光学耦合,以增加有效视野并识别各个闪烁体元件。对新系统的测试表明,这些结构的光学特性使得从探测器表面的整个有效区域中辨别探测器元件成为可能。在先前的系统中,顶部和底部行以及左侧和右侧列是无法识别的。此外,使用新的光导使各个探测器元件的对比度提高了多达129%。对元件识别的改进使空间分辨率提高了约12%。由于光在光导中的衰减,探测器能量分辨率从18.5%降至19.1%。总体而言,这些改进应会提高专用乳腺PET系统的视野和空间分辨率。