Gnanaraj Pushpa, Karthikeyan Subashini, Narasimhan Murali, Rajagopalan Vaidyanathan
Department of Dermatology, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram, Tamil Nadu, India.
Indian J Dermatol. 2015 Sep-Oct;60(5):461-4. doi: 10.4103/0019-5154.164358.
Acne is a common disorder among adolescents and young adults causing a considerable psychological impact including anxiety and depression. Isotretinoin, a synthetic oral retinoid is very effective in the treatment of moderate to severe acne. But there have been many reports linking isotretinoin to depression and suicide though no clear proof of association has been established so far.
To determine whether oral isotretinoin increases the risk of depression in patients with moderate to severe acne.
One hundred and fifty patients with moderate to severe acne were treated with oral isotretinoin 0.5 mg/kg/day for a period of 3 months. Their acne and depression scoring was done at baseline and then every month for the first 3 months and then at 6 months.
We found that the acne scoring reduced from 3.11 ± 0.49 to 0.65 ± 0.62 (P = < 0.001) at the end of 3 months. Also, the depression scoring decreased significantly from 3.89 ± 4.9 at the beginning of study to 0.45 ± 1.12 (P < 0.001) at the end of 3 months. Both the acne and depression scores continued to remain low at the end of 6 months at 0.5 ± 0.52 (P = < 0.001) and 0.18 ± 0.51 (P = < 0.001), respectively.
Our study proves that oral isotretinoin causes significant clearance of acne lesions. It causes significant reduction in depression scores and is not associated with an increased incidence of depression or suicidal tendencies.
痤疮是青少年和青年中的常见疾病，会造成相当大的心理影响，包括焦虑和抑郁。异维甲酸是一种合成口服类维生素A，在治疗中度至重度痤疮方面非常有效。但有许多报告将异维甲酸与抑郁和自杀联系起来，尽管目前尚未确立明确的关联证据。
确定口服异维甲酸是否会增加中度至重度痤疮患者的抑郁风险。
150例中度至重度痤疮患者接受口服异维甲酸治疗，剂量为0.5毫克/千克/天，为期3个月。在基线时对他们的痤疮和抑郁进行评分，然后在最初3个月内每月评分一次，之后在6个月时评分。
我们发现，3个月末痤疮评分从3.11±0.49降至0.65±0.62（P =<0.001）。此外，抑郁评分从研究开始时的3.89±4.9显著降至3个月末的0.45±1.12（P<0.001）。在6个月末，痤疮和抑郁评分分别继续保持在较低水平，为0.5±0.52（P =<0.001）和0.18±0.51（P =<0.001）。
我们的研究证明，口服异维甲酸可显著清除痤疮皮损。它能显著降低抑郁评分，且与抑郁或自杀倾向的发生率增加无关。
