Bettoli Vincenzo, Guerra-Tapia Aurora, Herane Maria Isabel, Piquero-Martín Jaime
Department of Clinical Medicine and Oncology, O.U. Dermatology, Teaching Hospital, Azienda Ospedaliera - University of Ferrara, Ferrara, Italy.
Member of Global Alliance to Improve Outcomes in Acne, Philadelphia, PA, USA.
Clin Cosmet Investig Dermatol. 2019 Dec 30;12:943-951. doi: 10.2147/CCID.S234231. eCollection 2019.
Acne vulgaris affects more than 80% of adolescents and young adults and forms a substantial proportion of the dermatologist's and general practitioner's caseload. Severity of symptoms varies but may result in facial scarring and psychological repercussions. Oral isotretinoin is highly effective but can only be prescribed by specialists. Side effects are recognized and mostly predictable, ranging from cosmetic effects to teratogenicity. These can affect patients' quality of life and treatment adherence. This article provides a commentary on 4 key areas: the use of oral isotretinoin vs oral antibiotics, including the importance of early recognition of nonresponse to treatment, the psychological effects of acne and isotretinoin treatment, the side effects of isotretinoin therapy, and cosmetic treatment options that can help alleviate predictable side effects. The authors, who have all participated in various international expert groups, draw on relevant literature and their extensive professional experience with oral isotretinoin in the treatment of acne. The aim of this article is to provide an informative and practical approach to managing oral isotretinoin treatment in patients with acne, to help optimize treatment of this skin disease.
寻常痤疮影响超过80%的青少年和青年成人，在皮肤科医生和全科医生的病例中占相当大的比例。症状的严重程度各不相同，但可能导致面部瘢痕形成和心理影响。口服异维A酸非常有效，但只能由专科医生开处方。副作用是已知的，而且大多是可预测的，从美容影响到致畸性不等。这些会影响患者的生活质量和治疗依从性。本文对四个关键领域进行了评论：口服异维A酸与口服抗生素的使用，包括早期识别治疗无反应的重要性、痤疮和异维A酸治疗的心理影响、异维A酸治疗的副作用，以及有助于减轻可预测副作用的美容治疗选择。所有作者都参与了多个国际专家组，他们借鉴了相关文献以及他们在口服异维A酸治疗痤疮方面的丰富专业经验。本文的目的是提供一种信息丰富且实用的方法来管理痤疮患者的口服异维A酸治疗，以帮助优化这种皮肤病的治疗。
