蛋白质组学在牙科学生理和病理状况中的作用：综述

Role of proteomics in physiologic and pathologic conditions of dentistry: Overview.

作者信息

Yoithapprabhunath Thukanayakanpalayam Ragunathan, Nirmal Ramadas Madhavan, Santhadevy Arumugam, Anusushanth Abraham, Charanya Duraisamy, Sri Chinthu K K, Yamunadevi Andamuthu

机构信息

Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women, Tiruchengode, Tamilnadu, India.

Department of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College and Hospital, Chidambaram, Tamilnadu, India.

出版信息

J Pharm Bioallied Sci. 2015 Aug;7(Suppl 2):S344-9. doi: 10.4103/0975-7406.163448.

DOI:10.4103/0975-7406.163448

PMID:26538875

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4606617/

Abstract

Proteomics is the study of structure and function of proteins in a large scale. For any living organism, preteins are considered to be the vital part because of its role in metabolic pathways of cells. These proteins not only play a role in physiological condition of the cell but also in altered manner during pathologic conditions. These altered proteins in diseased conditions are called as biomarkers. Several such biomarkers were identified in oral diseaes. This review is a brief note on proteins involved in odontogenesis and list of altered proteins proteins identified in various dental and oral diseases. The knowledge about the role of proteomics in dentistry and the importance of proteomic studies in early diagnosis and prognostic part of oral diseases helps in appliction of precised and sucessful treatment.

摘要

蛋白质组学是对蛋白质的结构和功能进行大规模研究。对于任何生物体而言，蛋白质因其在细胞代谢途径中的作用而被视为至关重要的部分。这些蛋白质不仅在细胞的生理状态中发挥作用，而且在病理状态下也会以改变的方式发挥作用。疾病状态下这些改变的蛋白质被称为生物标志物。在口腔疾病中已鉴定出多种此类生物标志物。本综述简要介绍了参与牙胚发生的蛋白质，以及在各种牙齿和口腔疾病中鉴定出的改变蛋白质列表。了解蛋白质组学在牙科中的作用以及蛋白质组学研究在口腔疾病早期诊断和预后方面的重要性，有助于实施精确且成功的治疗。