蛋白质组学：在人类医学中的概念与应用
Proteomics: Concepts and applications in human medicine.
作者信息
Al-Amrani Safa, Al-Jabri Zaaima, Al-Zaabi Adhari, Alshekaili Jalila, Al-Khabori Murtadha
机构信息
Department of Microbiology and Immunology, Sultan Qaboos University, Muscat 123, Oman.
Department of Human and Clinical Anatomy, Sultan Qaboos University, Muscat 123, Oman.
出版信息
World J Biol Chem. 2021 Sep 27;12(5):57-69. doi: 10.4331/wjbc.v12.i5.57.
Abstract
Proteomics is the complete evaluation of the function and structure of proteins to understand an organism's nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Therefore, combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease alteration. However, most studies have investigated a small part of the proteins in the blood. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.
摘要
蛋白质组学是对蛋白质的功能和结构进行全面评估，以了解生物体的本质。质谱分析法是用于分析细胞中蛋白质谱的重要工具。然而，由于生物标志物的复杂性和动态性，生物标志物的发现仍然是蛋白质组学的主要挑战。因此，将蛋白质组学方法与基因组学和生物信息学相结合，将有助于理解生物系统及其疾病改变的信息。然而，大多数研究只调查了血液中的一小部分蛋白质。本综述重点介绍了蛋白质组学的类型、可用的蛋白质组学技术及其在不同研究领域的应用。
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