Otvös L, Tegyey Z, Vereczkey L, Ledniczky M, Tamás J, Pálosi E, Szporny L
Drug Metab Dispos. 1978 May-Jun;6(3):213-7.
The metabolism of (-)-4,5-dihydrodiazepam (7-chloro-1,3,4,5-tetrahydro-1-methyl-5-phenyl-2H-1,4-benzo[2-14C]diazepin-2-one) (I) was investigated in rats. Metabolites from urine and bile extracts purified by thin-layer chromatography were identified by mass spectrometry. Diazepam and its main metabolites were found among the biotransformation products of I. Based on these findings, the most important identified metabolic route of the compound studied appears to be the formation of an unsaturated bond between the N4 and C5 atoms, and further transformation of the diazepam formed.
在大鼠体内研究了（-）-4,5-二氢地西泮（7-氯-1,3,4,5-四氢-1-甲基-5-苯基-2H-1,4-苯并[2-¹⁴C]二氮䓬-2-酮）（I）的代谢情况。通过薄层色谱法纯化的尿液和胆汁提取物中的代谢产物用质谱法进行鉴定。在地西泮及其主要代谢产物中发现了I的生物转化产物。基于这些发现，所研究化合物最重要的已鉴定代谢途径似乎是在N4和C5原子之间形成一个不饱和键，以及所形成的地西泮的进一步转化。
