苯丙香豆素在大鼠体内的生物转化。
Biotransformation of phenprocoumon in the rat.
作者信息
Pohl L R, Haddock R E, Trager W F
出版信息
J Med Chem. 1975 May;18(5):519-23.
PMID:1151963
Abstract
The metabolic fate of phenprocoumon [3-(alpha-ethylbenzyl)-4-hydroxycoumarin] in the rat is described. The major metabolites, 4',-6-,7-, and 8-hyproxyphenprocoumon, have been identified yb mass spectrometry, TLC, and uv and compared with authentic smaples. Metabolites are mainly excreted via the feces. The results are compared with those previously reported for warfarin.
摘要
本文描述了苯丙香豆素[3-(α-乙基苄基)-4-羟基香豆素]在大鼠体内的代谢情况。主要代谢产物4'-、6-、7-和8-羟基苯丙香豆素已通过质谱、薄层色谱法、紫外光谱法鉴定，并与标准样品进行了比较。代谢产物主要通过粪便排出。将这些结果与先前报道的华法林的结果进行了比较。
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