溶骨性和成骨性骨骼病变的机制。
Mechanisms of osteolytic and osteoblastic skeletal lesions.
作者信息
David Roodman G, Silbermann Rebecca
机构信息
Department of Medicine, Hematology, Oncology, Indiana University , Indianapolis, IN, USA ; Richard L Roudebush VA Medical Center , Indianapolis, IN, USA.
Department of Medicine, Hematology, Oncology, Indiana University , Indianapolis, IN, USA.
出版信息
Bonekey Rep. 2015 Oct 28;4:753. doi: 10.1038/bonekey.2015.122. eCollection 2015.
Abstract
The bone is a frequent site for tumor metastasis, and cancer in the bone results in marked disturbances of bone remodeling that can be lytic, blastic or a combination of the two. Patients with advanced malignancies that have metastasized to the bone frequently suffer from debilitating skeletal-related events, including pathologic fractures, spinal cord compression syndromes, disorders of calcium and phosphate homeostasis and severe cancer-related pain. This review will discuss recent studies on the mechanisms responsible for osteolytic and osteoblastic metastasis and how their identification has resulted in the development of new agents for patients with metastatic bone disease.
摘要
骨骼是肿瘤转移的常见部位，骨癌会导致骨重塑明显紊乱，可表现为溶骨性、成骨性或两者兼具。已发生骨转移的晚期恶性肿瘤患者常遭受与骨骼相关的致残性事件，包括病理性骨折、脊髓压迫综合征、钙磷稳态紊乱以及严重的癌痛。本综述将讨论近期关于溶骨性和成骨性转移机制的研究，以及这些机制的确定如何促成了针对骨转移疾病患者的新型药物的研发。
相似文献
1
Mechanisms of osteolytic and osteoblastic skeletal lesions.溶骨性和成骨性骨骼病变的机制。
Bonekey Rep. 2015 Oct 28;4:753. doi: 10.1038/bonekey.2015.122. eCollection 2015.
2
A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone2 in natural killer cell-depleted severe combined immunodeficient mice.在自然杀伤细胞缺失的严重联合免疫缺陷小鼠中建立具有溶骨性和成骨性特性的人肺癌ACC-LC-319/bone2骨转移模型。
Oncol Res. 2009;17(11-12):581-91. doi: 10.3727/096504009789745511.
3
Imaging characteristic analysis of metastatic spine lesions from breast, prostate, lung, and renal cell carcinomas for surgical planning: Osteolytic versus osteoblastic.用于手术规划的乳腺癌、前列腺癌、肺癌和肾细胞癌脊柱转移瘤的影像学特征分析：溶骨性与成骨性
Surg Neurol Int. 2016 May 17;7(Suppl 13):S361-5. doi: 10.4103/2152-7806.182549. eCollection 2016.
4
Bisphosphonates for breast cancer.用于乳腺癌的双膦酸盐类药物。
Cochrane Database Syst Rev. 2005 Jul 20(3):CD003474. doi: 10.1002/14651858.CD003474.pub2.
5
Mixed metastatic lung cancer lesions in bone are inhibited by noggin overexpression and Rank:Fc administration.骨中混合性转移性肺癌病灶可被头蛋白过表达及Rank:Fc给药所抑制。
J Bone Miner Res. 2006 Oct;21(10):1571-80. doi: 10.1359/jbmr.060706.
6
PET Tracer F-Fluciclovine Can Detect Histologically Proven Bone Metastatic Lesions: A Preclinical Study in Rat Osteolytic and Osteoblastic Bone Metastasis Models.正电子发射断层显像（PET）示踪剂F-氟西克洛维能检测经组织学证实的骨转移病灶：大鼠溶骨性和成骨性骨转移模型的临床前研究
Theranostics. 2017 May 15;7(7):2048-2064. doi: 10.7150/thno.19883. eCollection 2017.
7
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.癌源性 hsa-miR-940 通过靶向 ARHGAP1 和 FAM134A 在骨转移微环境中诱导成骨表型。
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2204-2209. doi: 10.1073/pnas.1717363115. Epub 2018 Feb 12.
8
Animal model for mammary tumor growth in the bone microenvironment.骨微环境中乳腺肿瘤生长的动物模型。
Breast Cancer. 2013 Jul;20(3):195-203. doi: 10.1007/s12282-013-0439-5. Epub 2013 Jan 19.
9
Osteolytic and osteoblastic bone metastases: two extremes of the same spectrum?溶骨性和成骨性骨转移：同一谱系的两个极端？
Recent Results Cancer Res. 2012;192:225-33. doi: 10.1007/978-3-642-21892-7_11.
10
Semiquantitative assessment of osteoblastic, osteolytic, and mixed lytic-sclerotic bone lesions on fluorodeoxyglucose positron emission tomography/computed tomography and bone scintigraphy.氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描及骨闪烁显像上成骨性、溶骨性和混合性溶骨-硬化性骨病变的半定量评估
World J Nucl Med. 2019 Apr-Jun;18(2):132-136. doi: 10.4103/wjnm.WJNM_31_18.
引用本文的文献
1
Mechanical Loading of Osteocytes via Oscillatory Fluid Flow Regulates Early-Stage PC-3 Prostate Cancer Metastasis to Bone.通过振荡液流对骨细胞进行机械加载可调节PC-3前列腺癌早期骨转移。
Adv Biol (Weinh). 2025 Apr;9(4):e2400824. doi: 10.1002/adbi.202400824. Epub 2025 Feb 19.
2
Non-parathyroid hypercalcemia in a patient with new-onset hyperthyroidism and silicone-induced granulomas: case report.新发甲状腺功能亢进症合并硅诱导肉芽肿患者的非甲状旁腺高钙血症：病例报告
Front Endocrinol (Lausanne). 2025 Jan 21;15:1447652. doi: 10.3389/fendo.2024.1447652. eCollection 2024.
3
Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner.乳腺癌细胞以MRTF依赖的旁分泌方式促进破骨细胞分化。
Mol Biol Cell. 2025 Jan 1;36(1):ar8. doi: 10.1091/mbc.E24-06-0285. Epub 2024 Dec 4.
4
SERPINH1 modulates apoptosis by inhibiting P62 ubiquitination degradation to promote bone metastasis of prostate cancer.丝氨酸蛋白酶抑制剂H1（SERPINH1）通过抑制P62泛素化降解来调节细胞凋亡，从而促进前列腺癌的骨转移。
iScience. 2024 Jul 10;27(8):110427. doi: 10.1016/j.isci.2024.110427. eCollection 2024 Aug 16.
5
Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice.骨肉瘤诱导的疼痛是由脊髓背角的胶质细胞激活介导的，而非辣椒素敏感的伤害性神经元：小鼠的复杂功能和形态学特征
Cancers (Basel). 2024 May 7;16(10):1788. doi: 10.3390/cancers16101788.
6
Ancient Diseases in Vertebrates: Tumours through the Ages.脊椎动物中的古代疾病：历代肿瘤
Animals (Basel). 2024 May 15;14(10):1474. doi: 10.3390/ani14101474.
7
Role of the osteocyte in bone metastasis - The importance of networking.骨细胞在骨转移中的作用——网络连接的重要性。
J Bone Oncol. 2024 Jan 17;44:100526. doi: 10.1016/j.jbo.2024.100526. eCollection 2024 Feb.
8
A Novel Primary Cilium-Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells.一种新型的初级纤毛介导的机制，通过该机制成骨细胞调节乳腺癌和前列腺癌细胞的转移行为。
Adv Sci (Weinh). 2024 Jan;11(2):e2305842. doi: 10.1002/advs.202305842. Epub 2023 Nov 15.
9
Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity.美国中年女性队列中的乳腺癌与骨矿物质密度：与磷酸盐毒性的关联
Cancers (Basel). 2023 Oct 21;15(20):5093. doi: 10.3390/cancers15205093.
10
Spatially patterned 3D model mimics key features of cancer metastasis to bone.空间模式化 3D 模型模拟癌症转移到骨骼的关键特征。
Biomaterials. 2023 Aug;299:122163. doi: 10.1016/j.biomaterials.2023.122163. Epub 2023 May 18.
本文引用的文献
1
Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases.肿瘤在骨微环境中诱导产生的压力促使骨细胞促进前列腺癌骨转移的生长。
Cancer Res. 2015 Jun 1;75(11):2151-8. doi: 10.1158/0008-5472.CAN-14-2493. Epub 2015 Apr 8.
2
Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease.miR-135 和 miR-203 通过靶向 Runx2 抑制乳腺癌的进展和骨转移。
Cancer Res. 2015 Apr 1;75(7):1433-44. doi: 10.1158/0008-5472.CAN-14-1026. Epub 2015 Jan 29.
3
The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.成骨龛促进播散性乳腺癌细胞早期阶段的骨定植。
Cancer Cell. 2015 Feb 9;27(2):193-210. doi: 10.1016/j.ccell.2014.11.017. Epub 2015 Jan 15.
4
Role of osteocytes in multiple myeloma bone disease.骨细胞在多发性骨髓瘤骨病中的作用。
Curr Opin Support Palliat Care. 2014 Dec;8(4):407-13. doi: 10.1097/SPC.0000000000000090.
5
Bone marrow monocyte-/macrophage-derived activin A mediates the osteoclastogenic effect of IL-3 in multiple myeloma.骨髓单核细胞/巨噬细胞衍生的激活素A介导白细胞介素-3在多发性骨髓瘤中的破骨细胞生成作用。
Leukemia. 2014 Apr;28(4):951-4. doi: 10.1038/leu.2013.385. Epub 2013 Dec 26.
6
IL-17, an important prognostic factor and potential therapeutic target for breast cancer?白细胞介素-17，乳腺癌的一个重要预后因素和潜在治疗靶点？
Eur J Immunol. 2014 Feb;44(2):604-5. doi: 10.1002/eji.201343875.
7
Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis.肿瘤诱导的破骨细胞 miRNA 变化作为溶骨性骨转移的调节剂和生物标志物。
Cancer Cell. 2013 Oct 14;24(4):542-56. doi: 10.1016/j.ccr.2013.09.008.
8
Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma.骨髓瘤的初始临床表现与分子细胞遗传学分类之间的关系。
Leukemia. 2014 Feb;28(2):398-403. doi: 10.1038/leu.2013.258. Epub 2013 Sep 5.
9
BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.骨髓间充质基质细胞衍生的外泌体促进多发性骨髓瘤进展。
J Clin Invest. 2013 Apr;123(4):1542-55. doi: 10.1172/JCI66517.
10
Myeloma cells suppress osteoblasts through sclerostin secretion.骨髓瘤细胞通过分泌硬化蛋白抑制成骨细胞。
Blood Cancer J. 2011 Jun;1(6):e27. doi: 10.1038/bcj.2011.22. Epub 2011 Jun 24.
Zotero 插件