Venning Freja A, Wullkopf Lena, Erler Janine T
Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH) , Copenhagen , Denmark.
Front Oncol. 2015 Oct 20;5:224. doi: 10.3389/fonc.2015.00224. eCollection 2015.
Metastatic complications are responsible for more than 90% of cancer-related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multistep process, with each step involving intricate cross talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression.
转移性并发症导致了超过90%的癌症相关死亡。从孤立肿瘤发展到播散性转移性疾病是一个多步骤过程，每一步都涉及癌细胞与其非细胞环境——细胞外基质（ECM）之间复杂的相互作用。在癌症进展过程中，许多ECM蛋白发生显著失调，导致生化和生物力学变化，共同促进转移级联反应。在本综述中，总结了几种ECM蛋白对癌症转移这些多个步骤的影响。此外，我们强调了有前景的（临床前）临床数据，这些数据显示了靶向这些ECM大分子以预防癌症进展的益处。
