Liu Guo-Xiao, Xi Hong-Qing, Sun Xiao-Yan, Wei Bo
Guo-Xiao Liu, Hong-Qing Xi, Xiao-Yan Sun, Bo Wei, Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
World J Gastroenterol. 2015 Mar 7;21(9):2605-13. doi: 10.3748/wjg.v21.i9.2605.
The extracellular matrix component periostin is a secreted protein that functions as both a cell attachment protein and an autocrine or paracrine factor that signals through the cell adhesion molecule integrins αvβ3 and αvβ5. Periostin participates in normal physiological activities such as cardiac development, but is also involved in pathophysiological processes in vascular diseases, wound repair, bone formation, and tumor development. It is of increasing interest in tumor biology because it is frequently overexpressed in a variety of epithelial carcinomas and is functionally involved in multiple steps of metastasis progression. These include the maintenance of stemness, niche formation, EMT, the survival of tumor cells, and angiogenesis, all of which are indispensable for gastric cancer metastasis. Periostin has been reported to activate the PI-3K/AKT, Wnt, and FAK-mediated signaling pathways to promote metastasis. Therefore, periostin represents a potentially promising candidate for the inhibition of metastasis. In this review article, we summarize recent advances in knowledge concerning periostin, its antagonist PNDA-3, and their influence on such key processes in cancer metastasis as maintenance of stemness, niche formation, epithelial-to-mesenchymal transition, tumor cell survival, and angiogenesis. In particular, we focus our attention on the role of periostin in gastric cancer metastasis, speculate as to the usefulness of periostin as a therapeutic and diagnostic target for gastric cancer metastasis, and consider potential avenues for future research.
细胞外基质成分骨膜蛋白是一种分泌蛋白，它既作为细胞黏附蛋白发挥作用，又作为通过细胞黏附分子整合素αvβ3和αvβ5发出信号的自分泌或旁分泌因子。骨膜蛋白参与心脏发育等正常生理活动，但也涉及血管疾病、伤口修复、骨形成和肿瘤发展等病理生理过程。它在肿瘤生物学中越来越受关注，因为它在多种上皮癌中经常过度表达，并在转移进展的多个步骤中发挥功能作用。这些步骤包括干性维持、微环境形成、上皮-间质转化、肿瘤细胞存活和血管生成，所有这些对于胃癌转移都是不可或缺的。据报道，骨膜蛋白可激活PI-3K/AKT、Wnt和FAK介导的信号通路以促进转移。因此，骨膜蛋白是抑制转移的一个潜在有前景的候选物。在这篇综述文章中，我们总结了关于骨膜蛋白及其拮抗剂PNDA-3的最新知识进展，以及它们对癌症转移中干性维持、微环境形成、上皮-间质转化、肿瘤细胞存活和血管生成等关键过程的影响。特别是，我们将注意力集中在骨膜蛋白在胃癌转移中的作用，推测骨膜蛋白作为胃癌转移的治疗和诊断靶点的实用性，并考虑未来研究的潜在途径。
