Vinnikov Denis, Brimkulov Nurlan, Krasotski Viktor
1 Public Association "Lung Health ," Bishkek, Kyrgyzstan .
2 Kyrgyz State Medical Academy , Bishkek, Kyrgyzstan .
High Alt Med Biol. 2016 Mar;17(1):5-10. doi: 10.1089/ham.2015.0067. Epub 2015 Nov 5.
The aim of the current study was to assess a year-long impact of chronic intermittent exposure to hypoxia on blood pressure (BP) in healthy working middle-aged adults.
Data from pre-employment and annual screening of high-altitude mining company (elevation 4000 meters above sea level) were obtained for 472 workers aged 34.1 ± 7.8 years, working 2-week shifts, followed by 2 weeks of rest at low altitude (cumulative exposure 6 months). Overall systolic, diastolic BP change (ΔBP) were calculated, and tested in multivariate regression models in the entire group, as well as in different strata of BP.
Baseline systolic BP reduced from 123.2 ± 11.3 to 116.3 ± 13.1 mmHg (ΔBP 6.8 mmHg), diastolic BP from 76.7 ± 8.4 to 74.9 ± 8.4 mmHg (ΔBP -1.7 mmHg) (p < 0.001), both measured at low altitude before and after one year of exposure to chronic intermittent hypoxia. The greater the baseline BP, the more pronounced was BP decrease. In the most prevalent combined group of normal and high normal BP, both systolic and diastolic BP reduced after one year of high altitude exposure (p < 0.01). In multivariate adjusted models, none of exposures of interest were associated with ΔBP.
One-year intermittent exposure to hypobaric hypoxia in new hires for high-altitude mining company was not associated with BP increase.
本研究旨在评估长期慢性间歇性缺氧对健康在职中年成年人血压（BP）的影响。
获取了一家海拔4000米的高海拔采矿公司472名年龄为34.1±7.8岁的工人的入职前和年度筛查数据，这些工人工作2周轮班，然后在低海拔地区休息2周（累计暴露6个月）。计算了总体收缩压、舒张压变化（ΔBP），并在整个组以及不同血压分层的多变量回归模型中进行了测试。
在慢性间歇性缺氧暴露一年前后，在低海拔地区测量的基线收缩压从123.2±11.3降至116.3±13.1 mmHg（ΔBP为6.8 mmHg），舒张压从76.7±8.4降至74.9±8.4 mmHg（ΔBP为-1.7 mmHg）（p<0.001）。基线血压越高，血压下降越明显。在最常见的正常血压和正常高值血压组合组中，高海拔暴露一年后收缩压和舒张压均降低（p<0.01）。在多变量调整模型中，感兴趣的暴露因素均与ΔBP无关。
高海拔采矿公司新员工一年的间歇性低压缺氧暴露与血压升高无关。
