al-Farabi Kazakh National University, 71 al-Farabi avenue, Almaty, 050040, Kazakhstan.
Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation.
Sci Rep. 2022 Aug 16;12(1):13903. doi: 10.1038/s41598-022-18331-4.
Very little is known about the factors of healthy worker survival effect at high-altitude mines. We conducted this cohort observation of the new hires for a high-altitude gold mine in Kyrgyzstan with the aim to ascertain predictors of survival at work. All new hires in 2009 through 2012 for a high-altitude gold mine (3600-4500 m above sea level) were followed up to January 2022. We tested the association of demographic, physiological predictors and diagnoses at the pre-employment screening with non-survival at work in Cox proportional hazards yielding hazard ratios (HR) with their 95% confidence intervals (CI). The cumulative observation time was 5190 person-years. Blood pressure at pre-employment, lung function, the diagnoses of essential hypertension, chronic obstructive pulmonary disease (COPD) or any other analyzed physiological variables were not associated with non-survival at work. However, smoking (HR 1.55; 95% CI 1.10; 2.17) increased the likelihood of non-survival at work, independent of any diagnosis or lowland residence (HR 1.95; 95% CI 1.31; 2.90). Adjusted for covariates and all diagnoses, having chronic rheumatic fever (HR 10.95; 95% CI 2.92; 33.92), hemorrhoids (HR 1.32; 95% CI 1.01; 3.75), adhesive otitis (HR 1.74; 95% CI 1.05; 2.89) or obesity (HR 1.71; 95% CI 1.01; 2.88) were associated with non-survival at work with time. This prospective observation of new hires for a high-altitude mining operation demonstrated that selected diagnoses, smoking and lowland residence elevated the risk of early exit in prospective workers.
对于高海拔矿山中健康工人生存效应的因素知之甚少。我们对吉尔吉斯斯坦一座高海拔金矿的新员工进行了这项队列观察，旨在确定工作生存的预测因素。2009 年至 2012 年期间，所有在海拔 3600-4500 米以上的高海拔金矿新员工都进行了随访，随访至 2022 年 1 月。我们使用 Cox 比例风险模型测试了就业前筛查中的人口统计学和生理学预测因素及诊断与工作非生存的关联，得出风险比（HR）及其 95%置信区间（CI）。累积观察时间为 5190 人年。就业前血压、肺功能、原发性高血压、慢性阻塞性肺疾病（COPD）或任何其他分析的生理变量与工作非生存无关。然而，吸烟（HR 1.55；95%CI 1.10；2.17）增加了工作非生存的可能性，独立于任何诊断或低地居住（HR 1.95；95%CI 1.31；2.90）。调整协变量和所有诊断后，患有慢性风湿热（HR 10.95；95%CI 2.92；33.92）、痔疮（HR 1.32；95%CI 1.01；3.75）、粘连性中耳炎（HR 1.74；95%CI 1.05；2.89）或肥胖（HR 1.71；95%CI 1.01；2.88）与工作非生存有关。这项对高海拔矿山新员工的前瞻性观察表明，某些诊断、吸烟和低地居住增加了前瞻性工人早期离职的风险。
