Dong Jiawei, Wu Zhongjie, Liu Zhengyi, Liu Ping, Sun Peipei
College of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Materials Cycling and Pollution Control, Nanjing Normal University , Nanjing 210097, China.
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University , Nanjing 210023, China.
J Org Chem. 2015 Dec 18;80(24):12588-93. doi: 10.1021/acs.joc.5b01666. Epub 2015 Nov 13.
2-(Alkylamino)benzonitriles were synthesized via a rhodium-catalyzed cyanation on the aryl C-H bond and subsequent denitrosation of N-nitrosoarylamines using a removable nitroso as the directing group, in which N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) was used as the "CN" source. Various substituents on the aryl ring and amino group of N-nitrosoarylamines tolerated the reaction, and the corresponding products were achieved in moderate to good yields.
通过铑催化芳基C-H键的氰化反应，然后使用可去除的亚硝基作为导向基团对N-亚硝基芳胺进行脱亚硝基反应，合成了2-（烷基氨基）苯甲腈，其中N-氰基-N-苯基对甲基苯磺酰胺（NCTS）用作“CN”源。N-亚硝基芳胺的芳环和氨基上的各种取代基都能耐受该反应，并以中等至良好的产率得到相应产物。
