铑催化的通过双重 C-H 活化的芳基咪唑并[1,2-α]吡啶的直接双氰基化反应。
Rhodium-Catalyzed Direct Bis-cyanation of Arylimidazo[1,2-α]pyridine via Double C-H Activation.
机构信息
College of Chemistry and Molecular Engineering, School of Life Sciences, Zhengzhou University , No. 100 of Science Road, Zhengzhou, Henan 450001, P. R. China.
出版信息
J Org Chem. 2017 Jun 16;82(12):6022-6031. doi: 10.1021/acs.joc.6b03036. Epub 2017 Jun 5.
An efficient Cp*Rh(III)-catalyzed selective bis-cyanation of arylimidazo[1,2-α]pyridines with N-cyano-N-phenyl-p-methylbenzenesulfonamide via N-directed ortho double C-H activation has been developed. The reaction proceeds with broad functional group tolerance to furnish various cyanated imidazopyridines in high yields. The current methodology exhibits unique characteristics, including high bis-cyanation selectivity, operational convenience, and gram-scale production.
发展了一种高效的 Cp*Rh(III)-催化的通过 N 导向的邻位双 C-H 活化的芳基咪唑并[1,2-α]吡啶的 N-氰基-N-苯基-p-甲苯磺酰胺的双氰化选择性反应。该反应具有广泛的官能团容忍性，可高收率得到各种氰化的咪唑并吡啶。该方法具有独特的特点，包括高双氰化选择性、操作方便和克级规模生产。
Zotero 插件