Ivanov A S, Medvedev A E, Buneeva O A, Gnedenko O V, Ershov P V, Mezencev Y V, Yablokov E O, Kaluzhsky L A, Florinskaya A V, Moskaleva N E, Zgoda V G
Institute of Biomedical Chemistry, Moscow, Russia.
Biomed Khim. 2015 Sep-Oct;61(5):632-5. doi: 10.18097/PBMC20156105632.
Isatin-binding activity of mice liver proteins has been investigated in the samples from the control and flight groups by using the methods of biosensor and proteomic analysis. It was found the higher isatin-binding activity in mice of flight group. The content of a number of individual isatin-binding proteins in the samples of the flight groups differ slightly from the ground control. However, in samples from animals which have weekly post-flight adaptation, the level of certain proteins was significantly increased. The latter allows us to assume that the main events in the proteome of mice (at least in subproteome of isatin-binding proteins), occurs in early post-flight period.
通过生物传感器和蛋白质组学分析方法，对对照组和飞行组小鼠肝脏蛋白质的异吲哚酮结合活性进行了研究。结果发现飞行组小鼠的异吲哚酮结合活性较高。飞行组样本中许多个体异吲哚酮结合蛋白的含量与地面对照组略有不同。然而，在飞行后每周适应性训练的动物样本中，某些蛋白质的水平显著增加。后者使我们能够假设，小鼠蛋白质组中的主要事件（至少在异吲哚酮结合蛋白的亚蛋白质组中）发生在飞行后的早期阶段。
