KIR2DL3/HLA-C1基因型与克罗恩病易感性之间存在显著关联。
Significant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn's disease.
作者信息
Díaz-Peña Roberto, Vidal-Castiñeira Jose Ramón, Moro-García Marco Antonio, Alonso-Arias Rebeca, Castro-Santos Patricia
机构信息
Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain; Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile.
Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.
出版信息
Hum Immunol. 2016 Jan;77(1):104-109. doi: 10.1016/j.humimm.2015.10.020. Epub 2015 Nov 2.
We aimed to analyze the possible association of KIR/HLA-C genotypes with the susceptibility to Crohn's disease (CD) in a Spanish population. A total of 125 patients with CD and 339 healthy controls were selected for this study. KIR and HLA-C typing were developed by sequence-specific oligonucleotide probing. We found that the centromeric A/A genotype and HLA-C1 combination was significantly increased in CD patients (P<10(-3)). The KIR2DL3/2DL3 genotype was significantly increased in CD patients (P<0.0005). Moreover, we also observed a highly significant increase of KIR2DL3-HLA-C1 homozygosis in CD patients (P<0.0005). Our results confirm the relevance of the KIR2DL2/KIR2DL3 genes and their interaction with HLA-C to CD. We show that the contribution of the KIR genes to CD susceptibility extends beyond the association with individual KIRs, with an imbalance between activating and inhibitory KIR genes seeming to influence the susceptibility to CD.
我们旨在分析西班牙人群中杀伤细胞免疫球蛋白样受体（KIR）/人类白细胞抗原C（HLA-C）基因型与克罗恩病（CD）易感性之间的可能关联。本研究共选取了125例CD患者和339名健康对照。采用序列特异性寡核苷酸探针技术进行KIR和HLA-C分型。我们发现，着丝粒A/A基因型与HLA-C1组合在CD患者中显著增加（P<10⁻³）。KIR2DL3/2DL3基因型在CD患者中显著增加（P<0.0005）。此外，我们还观察到CD患者中KIR2DL3-HLA-C1纯合性显著增加（P<0.0005）。我们的结果证实了KIR2DL2/KIR2DL3基因及其与HLA-C的相互作用与CD的相关性。我们表明，KIR基因对CD易感性的影响超出了与单个KIR的关联，激活和抑制性KIR基因之间的失衡似乎影响了CD的易感性。
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