Price Christopher A
Faculty of Veterinary MedicineCentre de recherche en reproduction animale, University of Montreal, 3200 rue Sicotte, St-Hyacinthe, Quebec, Canada J2S 7C6
J Endocrinol. 2016 Feb;228(2):R31-43. doi: 10.1530/JOE-15-0414. Epub 2015 Nov 5.
Fibroblast growth factors (FGFs) have been shown to alter growth and differentiation of reproductive tissues in a variety of species. Within the female reproductive tract, the effects of FGFs have been focused on the ovary, and the most studied one is FGF2, which stimulates granulosa cell proliferation and decreases differentiation (decreased steroidogenesis). Other FGFs have also been implicated in ovarian function, and this review summarizes the effects of members of two subfamilies on ovarian function; the FGF7 subfamily that also contains FGF10, and the FGF8 subfamily that also contains FGF18. There are data to suggest that FGF8 and FGF18 have distinct actions on granulosa cells, despite their apparent similar receptor binding properties. Studies of non-reproductive developmental biology also indicate that FGF8 is distinct from FGF18, and that FGF7 is also distinct from FGF10 despite similar receptor binding properties. In this review, the potential mechanisms of differential action of FGF7/FGF10 and FGF8/FGF18 during organogenesis will be reviewed and placed in the context of follicle development. A model is proposed in which FGF8 and FGF18 differentially activate receptors depending on the properties of the extracellular matrix in the follicle.
成纤维细胞生长因子（FGFs）已被证明可改变多种物种生殖组织的生长和分化。在雌性生殖道内，FGFs的作用主要集中在卵巢，研究最多的是FGF2，它可刺激颗粒细胞增殖并减少分化（降低类固醇生成）。其他FGFs也与卵巢功能有关，本综述总结了两个亚家族成员对卵巢功能的影响；FGF7亚家族还包含FGF10，FGF8亚家族还包含FGF18。有数据表明，尽管FGF8和FGF18具有明显相似的受体结合特性，但它们对颗粒细胞具有不同的作用。非生殖发育生物学的研究也表明，FGF8与FGF18不同，FGF7与FGF10也不同，尽管它们具有相似的受体结合特性。在本综述中，将对FGF7/FGF10和FGF8/FGF18在器官发生过程中差异作用的潜在机制进行综述，并结合卵泡发育的背景进行探讨。提出了一个模型，其中FGF8和FGF18根据卵泡中细胞外基质的特性差异激活受体。
