Ivaskiene Tatjana, Kaspute Greta, Bareikiene Egle, Prentice Urte
State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08410 Vilnius, Lithuania.
Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology (FTMC), Sauletekio Av. 3, LT-10257 Vilnius, Lithuania.
Int J Mol Sci. 2025 Mar 5;26(5):2317. doi: 10.3390/ijms26052317.
Preserving ovarian function is important to women's reproductive health. It is necessary for fertility and maintaining the overall hormonal balance. Platelet-rich plasma (PRP) is an autologous plasma containing a predominately platelet concentrate prepared from fresh blood. It has been observed that PRP injections into the ovary can renew the functional cells of the cortical layer of the ovary follicles and reactivate the production of sex hormones. It may improve a woman's fertility in the case of premature ovarian failure, the condition after chemotherapy treatment, or during the climacteric period. The main markers to evaluate the procedure's success are elevated anti-Müllerin hormone and enlarged count level of atrial follicles in ovaries. The aim of this review is to identify the ovarian PRP procedure success markers and point out the electrochemical sensor techniques. Literature was selected depending on including and excluding criteria; studies were sorted by topics in two blocks: PRP biomarkers and electrochemistry. As PRP acts as a regenerative care, electrochemical biosensors can provide accurate, real-time data to evaluate the biological response to PRP therapy. The biosensors' ability to monitor hormonal levels and follicle development serves as objective markers of the effectiveness of PRP in restoring ovarian function. Together, these approaches enable a more precise evaluation of ovarian health and fertility outcomes after PRP intervention.
保留卵巢功能对女性生殖健康至关重要。它对生育和维持整体激素平衡是必要的。富血小板血浆（PRP）是一种自体血浆，主要包含从新鲜血液中制备的血小板浓缩物。据观察，向卵巢注射PRP可使卵巢卵泡皮质层的功能细胞更新，并重新激活性激素的产生。在卵巢早衰、化疗后或更年期期间，它可能会提高女性的生育能力。评估该手术成功的主要指标是抗苗勒管激素升高和卵巢中窦卵泡计数水平增加。本综述的目的是确定卵巢PRP手术的成功指标，并指出电化学传感器技术。根据纳入和排除标准选择文献；研究按主题分为两个板块：PRP生物标志物和电化学。由于PRP具有再生护理作用，电化学生物传感器可以提供准确的实时数据，以评估对PRP治疗的生物学反应。生物传感器监测激素水平和卵泡发育的能力可作为PRP恢复卵巢功能有效性的客观指标。这些方法共同能够更精确地评估PRP干预后的卵巢健康和生育结果。
