Rosin Susanna, Ojansivu Ilkka, Kopu Aino, Keto-Tokoi Malin, Gylling Helena
Raisio Group, Benecol Unit, P.O. Box 101, FI-21201 Raisio, Finland.
University of Helsinki and Helsinki University Hospital, Internal Medicine, P.O. Box 700, 00029 Helsinki, Finland.
Cholesterol. 2015;2015:706970. doi: 10.1155/2015/706970. Epub 2015 Oct 12.
Plant stanol ester is a natural compound which is used as a cholesterol-lowering ingredient in functional foods and food supplements. The safety and efficacy of plant stanol ester have been confirmed in more than 70 published clinical studies and the ingredient is a well-established and widely recommended dietary measure to reduce serum cholesterol. Daily intake of 2 g plant stanols as plant stanol ester lowers LDL-cholesterol by 10%, on average. In Europe, foods with added plant stanol ester have been on the market for 20 years, and today such products are also available in many Asian and American countries. Despite the well-documented efficacy, the full potential in cholesterol reduction may not be reached if plant stanol ester is not used according to recommendations. This review therefore concentrates on the optimal use of plant stanol ester as part of dietary management of hypercholesterolemia. For optimal cholesterol lowering aiming at a lower risk of cardiovascular disease, plant stanol ester should be used daily, in sufficient amounts, with a meal and in combination with other recommended dietary changes.
植物甾烷醇酯是一种天然化合物，用作功能性食品和食品补充剂中的降胆固醇成分。超过70项已发表的临床研究证实了植物甾烷醇酯的安全性和有效性，该成分是一种成熟且广泛推荐的降低血清胆固醇的膳食措施。每天摄入2克作为植物甾烷醇酯的植物甾烷醇，平均可使低密度脂蛋白胆固醇降低10%。在欧洲，添加了植物甾烷醇酯的食品已上市20年，如今在许多亚洲和美洲国家也有此类产品。尽管其疗效有充分记录，但如果不按照建议使用植物甾烷醇酯，可能无法充分发挥其降低胆固醇的潜力。因此，本综述着重探讨植物甾烷醇酯作为高胆固醇血症饮食管理一部分的最佳使用方法。为了通过降低心血管疾病风险来实现最佳的胆固醇降低效果，应每天足量随餐使用植物甾烷醇酯，并结合其他推荐的饮食改变。
