Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell Stem Cell. 2015 Nov 5;17(5):509-25. doi: 10.1016/j.stem.2015.10.009.
Embryonic pluripotency can be recapitulated in vitro by a spectrum of pluripotent stem cell states stabilized with different culture conditions. Their distinct spatiotemporal characteristics provide an unprecedented tool for the study of early human development. The newly unveiled ability of some stem cell types for crossing xeno-barriers will facilitate the generation of interspecies chimeric embryos from distant species, including humans. When combined with efficient zygote genome editing technologies, xenogeneic human pluripotent stem cells may also open new frontiers for regenerative medicine applications, including the possibility of generating human organs in animals via interspecies chimeric complementation.
胚胎多能性可以通过一系列具有不同培养条件的多能干细胞状态在体外重现在。它们独特的时空特征为早期人类发育的研究提供了前所未有的工具。一些干细胞类型跨越异种障碍的新发现能力将促进来自远缘物种（包括人类）的种间嵌合胚胎的产生。当与高效的受精卵基因组编辑技术相结合时，异种人类多能干细胞也可能为再生医学应用开辟新的前沿，包括通过种间嵌合互补在动物中产生人类器官的可能性。
