Hyun Insoo
Department of Bioethics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Development. 2015 Jan 1;142(1):6-8. doi: 10.1242/dev.119206.
In recent years, there has been much interest in the prospect of generating and using human stem cells that exhibit a state of naïve pluripotency. Such a pluripotent state might be functionally confirmed by assessing the chimeric contribution of these cells to non-human blastocysts. Furthermore, the generation of naïve human pluripotent stem cells in vitro could lead to the creation of chimeric animal models that can facilitate the study of human development and disease. However, these lines of research raise thorny ethical concerns about the moral status of such chimeric animals. Here, I call attention to these ethical barbs and suggest a way in which to proceed cautiously.
近年来，人们对生成和使用表现出原始多能性状态的人类干细胞前景产生了浓厚兴趣。通过评估这些细胞对非人类囊胚的嵌合贡献，或许可以在功能上确认这种多能状态。此外，在体外生成原始人类多能干细胞可能会导致创建嵌合动物模型，从而有助于研究人类发育和疾病。然而，这些研究方向引发了关于此类嵌合动物道德地位的棘手伦理问题。在此，我提请关注这些伦理难题，并提出一种谨慎前行的方法。
