Saito T, Shiokawa A, Inoue S
Second Department of Pathology, Showa University School of Medicine, Tokyo, Japan.
Jpn Circ J. 1989 Jan;53(1):1-6. doi: 10.1253/jcj.53.1.
To determine abnormal immune regulation in biopsy-proven active and healed myocarditis cases, lymphatic subpopulations in myocardial tissue and peripheral blood were studied. Among 53 cases examined, 19 were active myocarditis (M) and 34 were healing or healed (HM). Five cases of myocarditis were studied sequentially. The percentages of pan T-cells, B-cells, helper/inducer T-cells (Th/i), suppressor/cytotoxic T-cells (Ts/c), etc per total marker positive cells were calculated by use of monoclonal antibodies. In myocardial tissue, the percentage of Th/i was significantly lower in HM than M (p less than 0.01). The helper/suppressor ratio (OKT4/8) in peripheral blood was 2.43 +/- 0.43 (mean +/- SE) in M, 1.61 +/- 0.19 in HM and 1.34 +/- 0.12 in age-matched controls. In 5 progressive studied cases of M, there was a decrease of the helper/suppressor ratio at 1 to 6 months after the myocarditis. It was concluded that subsidence of the immune reaction in myocardium is related to the healing process of myocarditis and may suggest improved prognosis.
为了确定经活检证实的活动性和愈合性心肌炎病例中的异常免疫调节，对心肌组织和外周血中的淋巴亚群进行了研究。在检查的53例病例中，19例为活动性心肌炎（M），34例为正在愈合或已愈合（HM）。对5例心肌炎病例进行了连续研究。使用单克隆抗体计算每种总标记阳性细胞中全T细胞、B细胞、辅助/诱导性T细胞（Th/i）、抑制/细胞毒性T细胞（Ts/c）等的百分比。在心肌组织中，HM组的Th/i百分比显著低于M组（p<0.01）。外周血中的辅助/抑制比（OKT4/8）在M组为2.43±0.43（平均值±标准误），在HM组为1.61±0.19，在年龄匹配的对照组中为1.34±0.12。在5例进行性研究的M组病例中，心肌炎后1至6个月辅助/抑制比下降。得出的结论是，心肌中免疫反应的消退与心肌炎的愈合过程有关，可能提示预后改善。
