Kishimoto C, Tomioka N, Tamaki S, Kawai C
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Jpn Circ J. 1988 Jan;52(1):94-8. doi: 10.1253/jcj.52.94.
Immunological identification of lymphocyte subsets in a patient with myocarditis revealed an increase in myocardial OKT 11 (pan T), OKT 4 (inducer/helper T) and OKT 8 (suppressor/cytotoxic T) subsets associated with a transient decrease in the percentage of circulating OKT 3 (pan T) and OKT 4 (inducer/helper T) subsets. This decrease may be explained by the accumulation of these subsets in the diseased myocardium. Specific antigenic markers on lymphocytes at the site of myocardial inflammation in the acute stage of myocarditis differ from those on corresponding peripheral lymphocytes. This observation may highlight the immuno-pathogenetic mechanisms involved in the development of myocarditis.
对一名心肌炎患者淋巴细胞亚群的免疫学鉴定显示，心肌中OKT 11（全T细胞）、OKT 4（诱导/辅助性T细胞）和OKT 8（抑制/细胞毒性T细胞）亚群增加，同时循环中的OKT 3（全T细胞）和OKT 4（诱导/辅助性T细胞）亚群百分比出现短暂下降。这种下降可能是由于这些亚群在病变心肌中积聚所致。心肌炎急性期心肌炎症部位淋巴细胞上的特异性抗原标志物与相应外周淋巴细胞上的不同。这一观察结果可能突出了心肌炎发生过程中涉及的免疫发病机制。
