Chen Li-Chi, Hsu Ju-Wei, Huang Kai-Lin, Bai Ya-Mei, Su Tung-Ping, Li Cheng-Ta, Yang Albert C, Chang Wen-Han, Chen Tzeng-Ji, Tsai Shih-Jen, Chen Mu-Hong
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
J Affect Disord. 2016 Jan 15;190:282-285. doi: 10.1016/j.jad.2015.10.030. Epub 2015 Oct 27.
Several cross-sectional studies suggested a link between endometriosis and mood disorders. However, the temporal association between endometriosis and mood disorders (depression and anxiety disorders) is still unclear.
Using the Taiwan National Health Insurance Research Database, 10,439 women with endometriosis and 10,439 (1:1) age-/sex-matched controls between 1998 and 2009 were enrolled, and followed up to the end of 2011. Those who developed depression or anxiety disorders during the follow-up were identified.
Women with endometriosis had an increased risk of developing major depression (hazard ratio [HR]: 1.56, 95% confidence interval [CI]:1.24-1.97), any depressive disorder (HR: 1.44, 95% CI: 1.25-1.65), and anxiety disorders (HR: 1.44, 95% CI: 1.22-1.70) in later life compared to those without endometriosis. Stratified by age group, women with endometriosis aged <40 years and those aged ≧40 years were both prone to developing major depression (HR: 1.52, 95% CI: 1.15-1.99; HR: 1.69, 95% CI: 1.09-2.62), any depressive disorder (HR: 1.43, 95% CI: 1.21-1.69; HR: 1.45, 95% CI: 1.13-1.56), and anxiety disorders (HR: 1.39, 95% CI: 1.14-1.71; HR: 1.53, 95% CI: 1.15-2.04).
the incidence of depression and anxiety disorders may be underestimated since only those who sought medical consultation and help would be enrolled in our study.
Endometriosis was associated with an elevated likelihood of developing depression and anxiety disorders. Further studies may be required to investigate the underlying pathophysiology between endometriosis and both depression and anxiety disorders.
多项横断面研究表明子宫内膜异位症与情绪障碍之间存在关联。然而，子宫内膜异位症与情绪障碍（抑郁症和焦虑症）之间的时间关联仍不明确。
利用台湾国民健康保险研究数据库，纳入了1998年至2009年间10439例患有子宫内膜异位症的女性以及10439例（1:1）年龄和性别匹配的对照，并随访至2011年底。确定随访期间出现抑郁症或焦虑症的患者。
与没有子宫内膜异位症的女性相比，患有子宫内膜异位症的女性在晚年患重度抑郁症（风险比[HR]：1.56，95%置信区间[CI]：1.24 - 1.97）、任何抑郁症（HR：1.44，95%CI：1.25 - 1.65）和焦虑症（HR：1.44，95%CI：1.22 - 1.70）的风险增加。按年龄组分层，年龄<40岁和年龄≥40岁的患有子宫内膜异位症的女性均容易患重度抑郁症（HR：1.52，95%CI：1.15 - 1.99；HR：1.69，95%CI：1.09 - 2.62）、任何抑郁症（HR：1.43，95%CI：1.21 - 1.69；HR：1.45，95%CI：1.13 - 1.56）和焦虑症（HR：1.39，95%CI：1.14 - 1.71；HR：1.53，95%CI：1.15 - 2.04）。
由于只有那些寻求医疗咨询和帮助的患者才会纳入我们的研究，抑郁症和焦虑症的发病率可能被低估。
子宫内膜异位症与患抑郁症和焦虑症的可能性增加有关。可能需要进一步研究来调查子宫内膜异位症与抑郁症和焦虑症之间潜在的病理生理学关系。
