Kasantikul V, Shuangshoti S
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Surg Oncol. 1989 May;41(1):22-6. doi: 10.1002/jso.2930410109.
Twenty vertebral bones, 11 costal, 11 epiglottic, six tracheal, and five bronchial cartilages and seven chordomas were evaluated by the application of peroxidase-antiperoxidase (PAP) indirect immunohistochemical method for localization of glial fibrillary acidic protein (GFAP). Positive immunostaining for GFAP was observed in osteocytes of normal bone (13/20), chondrocytes of normal epiglottis (5/11), costal cartilage (3/11), trachea (2/6), and bronchus (4/5). Four of seven chordomas had neoplastic cells that exhibited cytoplasmic positivity to GFAP. These findings suggested that osteocytes, chondrocytes, and chordoma cells have cytoskeletal intermediate filaments that are antigenically identical to or similar to or associated with GFAP.
应用过氧化物酶-抗过氧化物酶（PAP）间接免疫组织化学方法对20块椎骨、11块肋骨、11块会厌软骨、6块气管软骨、5块支气管软骨和7例脊索瘤进行评估，以定位胶质纤维酸性蛋白（GFAP）。在正常骨的骨细胞（13/20）、正常会厌软骨细胞（5/11）、肋软骨（3/11）、气管（2/6）和支气管（4/5）中观察到GFAP阳性免疫染色。7例脊索瘤中有4例的肿瘤细胞对GFAP呈细胞质阳性。这些发现表明，骨细胞、软骨细胞和脊索瘤细胞具有与GFAP抗原性相同、相似或相关的细胞骨架中间丝。
