Hume D A, Donahue R E, Fidler I J
Department of Cell Biology, M.D. Anderson Cancer Center, Houston, TX 77030.
Lymphokine Res. 1989 Spring;8(1):69-77.
This paper investigates the effect of recombinant human macrophage colony-stimulating factor (CSF-1) on the interaction between mononuclear phagocytes and the metastatic murine melanoma, B16/B16. CSF-1 had no effect on the ability of primary or bone marrow-derived macrophages to kill B16 cells in vitro, nor on their activation for cytotoxicity by gamma interferon plus LPS. However, when administered in vivo, CSF-1 increased the number of monocytes and peritoneal cells in tumor-bearing animals, and led to a significant reduction in the appearance of pulmonary and extra-pulmonary metastatic lesions derived from primary B16 tumors. The results suggest a therapeutic potential for CSF-1 in the treatment of malignancy.
本文研究了重组人巨噬细胞集落刺激因子（CSF-1）对单核吞噬细胞与转移性小鼠黑色素瘤B16/B16之间相互作用的影响。CSF-1对原代或骨髓来源的巨噬细胞在体外杀伤B16细胞的能力没有影响，对γ干扰素加脂多糖激活其细胞毒性也没有影响。然而，当在体内给药时，CSF-1增加了荷瘤动物体内单核细胞和腹腔细胞的数量，并导致源自原发性B16肿瘤的肺和肺外转移病灶的出现显著减少。结果表明CSF-1在恶性肿瘤治疗中具有治疗潜力。
