18F-FDG PET/CT 预测胸腺癌世界卫生组织恶性程度的价值：重点关注基于体积的参数。
Value of 18F-FDG PET/CT for Predicting the World Health Organization Malignant Grade of Thymic Epithelial Tumors: Focused in Volume-Dependent Parameters.
机构信息
From the *Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Suwon; †Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul; ‡Department of Thoracic and Cardiovascular Surgery, National Health Insurance Service Ilsan Hospital, Gyeonggi; and §Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
出版信息
Clin Nucl Med. 2016 Jan;41(1):15-20. doi: 10.1097/RLU.0000000000001032.
PURPOSE
We investigated whether preoperative parameters of 18F-FDG PET/CT were correlated with the World Health Organization (WHO) classification and/or Masaoka staging of thymic epithelial tumors.
PATIENTS AND METHODS
We reviewed 61 patients retrospectively who were diagnosed with thymic epithelial tumors after surgical resection and PET/CT. A volume of interest was drawn on the primary lesion, using an SUV cutoff of 2.5, and metabolic indices such as SUVmax, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured.
RESULTS
There were 24 male patients (38.7%), and the mean (SD) age was 50.23 (12.54) years. The mean (SD) tumor size was 6.11 (3.41) cm. There were 22 low-risk thymomas (36.9%) (A, AB, B1), 32 high-risk thymomas (51.6%), and 7 thymic carcinomas (11.5%). The Masaoka stage was I in 15 (24.6%), II in 30 (49.2%), III in 11 (18.0%), and IV in 5 patients (8.2%). Mean (SD) SUVmax was 3.43 (1.01) in low-risk thymomas, 4.42 (1.70) in high-risk thymomas, and 8.23 (2.61) in thymic carcinoma; the differences were significant (P < 0.001). Mean (SD) MTV and TLG were 90.74 (114.56) and 229.36 (300.56) in low-risk thymomas, 80.82 (112.49) and 233.93 (340.91) in high-risk thymomas, and 90.63 (90.74) and 390.94 (437.62), respectively, in thymic carcinomas. MTV and TLG showed no correlation with the WHO classification. On receiver operating characteristic curve analysis, the cutoff value for discriminating thymomas and thymic carcinomas was 5.05. SUVmax and TLG were correlated with Masaoka stage.
CONCLUSIONS
Although volume-dependent parameters were not correlated with the WHO classification, a significant relationship was observed between SUVmax and WHO classification and Masaoka stage.
目的
我们研究了 18F-FDG PET/CT 的术前参数是否与胸腺癌的世界卫生组织（WHO）分类和/或 Masaoka 分期相关。
方法
我们回顾性分析了 61 例经手术切除和 PET/CT 诊断为胸腺癌的患者。使用 SUV 截断值为 2.5 在原发性病变上绘制感兴趣区域，并测量 SUVmax、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）等代谢指标。
结果
24 例为男性（38.7%），平均（SD）年龄为 50.23（12.54）岁。平均（SD）肿瘤大小为 6.11（3.41）cm。22 例为低危胸腺瘤（A、AB、B1）（36.9%），32 例为高危胸腺瘤（51.6%），7 例为胸腺癌（11.5%）。Masaoka 分期为 I 期 15 例（24.6%），II 期 30 例（49.2%），III 期 11 例（18.0%），IV 期 5 例（8.2%）。低危胸腺瘤的 SUVmax 平均值（SD）为 3.43（1.01），高危胸腺瘤为 4.42（1.70），胸腺癌为 8.23（2.61），差异有统计学意义（P＜0.001）。低危胸腺瘤的 MTV 和 TLG 平均值（SD）分别为 90.74（114.56）和 229.36（300.56），高危胸腺瘤分别为 80.82（112.49）和 233.93（340.91），胸腺癌分别为 90.63（90.74）和 390.94（437.62）。MTV 和 TLG 与 WHO 分类无关。在受试者工作特征曲线分析中，鉴别胸腺瘤和胸腺癌的截断值为 5.05。SUVmax 和 TLG 与 Masaoka 分期相关。
结论
尽管体积依赖性参数与 WHO 分类无关，但 SUVmax 与 WHO 分类和 Masaoka 分期之间存在显著关系。
Zotero 插件