百日咳毒素的遗传学
Genetics of pertussis toxin.
作者信息
Gross R, Aricò B, Rappuoli R
机构信息
Sclavo Research Centre, Siena, Italy.
出版信息
Mol Microbiol. 1989 Jan;3(1):119-24. doi: 10.1111/j.1365-2958.1989.tb00111.x.
Abstract
Pertussis toxin (PT) is the major virulence factor of Bordetella pertussis. The cloning and nucleotide sequencing of the PT genes from B. pertussis, Bordetella parapertussis and Bordetella bronchiseptica has elucidated the evolution of the Bordetella species and allowed considerable advances towards the understanding of their gene expression and the development of safer vaccines against pertussis.
摘要
百日咳毒素（PT）是百日咳博德特氏菌的主要毒力因子。对来自百日咳博德特氏菌、副百日咳博德特氏菌和支气管败血博德特氏菌的PT基因进行克隆和核苷酸测序，阐明了博德特氏菌属的进化，并在理解其基因表达以及开发更安全的百日咳疫苗方面取得了重大进展。
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