Edye B V, Mandryk J A, Frommer M S, Healey S, Ferguson D A
National Institute of Occupational Health and Safety, Sydney, NSW.
Med J Aust. 1989 May 15;150(10):574, 576-8, 581. doi: 10.5694/j.1326-5377.1989.tb136695.x.
This article reports on the long-term results of a randomized controlled trial of non-pharmacological intervention for mildly-elevated levels of cardiovascular risk factors. The intervention consisted of individual counselling by occupational health professionals. From a population of 4607 volunteers who were working for Australian government organizations, a sample of 2489 subjects met the eligibility criteria for the trial, and 1937 subjects were available for follow-up examination three years later. Changes in the levels of risk factors favoured the interventional group marginally and appeared to vary with the sex, age and occupation of the subjects. A significant effect of intervention was noted for systolic blood pressure levels; however, although this interventional effect was more pronounced in men of 40 years of age or over and in administrative workers, clinically it was small. The results suggest that individual counselling, as undertaken in this study, generally is not effective in the long-term modification of mildly-elevated cardiovascular risk factors.
本文报道了一项针对轻度升高的心血管危险因素进行非药物干预的随机对照试验的长期结果。干预措施包括职业健康专业人员提供的个体咨询。从4607名在澳大利亚政府机构工作的志愿者群体中，抽取了2489名受试者符合试验的入选标准，三年后有1937名受试者可进行随访检查。危险因素水平的变化略微有利于干预组，并且似乎因受试者的性别、年龄和职业而异。观察到干预对收缩压水平有显著影响；然而，尽管这种干预效果在40岁及以上男性和行政人员中更为明显，但从临床角度来看，效果较小。结果表明，本研究中所采用的个体咨询，一般而言对长期改善轻度升高的心血管危险因素无效。
