Agha-Hosseini Farzaneh, Mohebbian Mina, Sarookani Mohammad-Reza, Harirchi Iraj, Mirzaii-Dizgah Iraj
Department of Oral and Maxillofacial Medicine, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Oral Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran AND Department of Oral and Maxillofacial Medicine, The Academy of Medical Sciences, Tehran, Iran.
Department of Oral and Maxillofacial Medicine, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2015 Aug;53(8):471-5.
Oral lichen planus (OLP) is classified as a potential malignant disorder, and epidermal growth factor (EGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva EGF among patients with OLP and oral squamous cell carcinoma (OSCC). A cross-sectional study was performed on 27 patients with OLP (10 reticular and 17 atrophic-erosive forms), 27 patients with OSCC and 27 healthy control group. The study was conducted at the Cancer Department, Clinic of Oral Medicine, Tehran University of Medical Sciences. The serum and saliva EGF were assayed by ELISA method. Statistical analysis of ANOVA was used. The mean serum EGF in OLP and OSCC patients was significantly lower compared to healthy control group (P<0.05), but no significant difference was observed between OLP and OSCC patients. There was no significant difference in mean salivary EGF among groups. As serum EGF levels appear to be statistically similar in OLP and OSCC, it seems that EGF might play a role in the pathogenesis of OLP and its cancerization.
口腔扁平苔藓（OLP）被归类为潜在恶性疾病，表皮生长因子（EGF）可能在癌症发展中起关键作用。本研究的目的是比较OLP患者与口腔鳞状细胞癌（OSCC）患者血清和唾液中的EGF水平。对27例OLP患者（10例网状型和17例萎缩糜烂型）、27例OSCC患者和27例健康对照组进行了一项横断面研究。该研究在德黑兰医科大学口腔医学诊所肿瘤科进行。采用ELISA法检测血清和唾液中的EGF。使用方差分析进行统计分析。与健康对照组相比，OLP和OSCC患者的血清EGF均值显著降低（P<0.05），但OLP患者与OSCC患者之间未观察到显著差异。各组唾液EGF均值无显著差异。由于OLP和OSCC患者的血清EGF水平在统计学上似乎相似，因此EGF可能在OLP及其癌变的发病机制中起作用。
