口腔扁平苔藓和口腔鳞状细胞癌患者血清及唾液中的胶原酶-3（基质金属蛋白酶-13）
Serum and saliva collagenase-3 (MMP-13) in patients with oral lichen planus and oral squamous cell carcinoma.
作者信息
Agha-Hosseini Farzaneh, Mirzaii-Dizgah Iraj
机构信息
DDS, MSc, Fellowship of Research Biology, Professor, Dental Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, The Academy of Medical Sciences, Tehran, Iran.
PhD, Professor, Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.
出版信息
Med J Islam Repub Iran. 2015 Jun 7;29:218. eCollection 2015.
BACKGROUND
Oral lichen planus (OLP) has been classified as a pre-malignant condition. Matrix metalloproteinase-13 (MMP-13) or collagenase-3 may play a key role in cancer development. The aim of this study was to compare serum and saliva MMP-13 between patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).
METHODS
This cross sectional study was performed on 30 patients with OLP (8 reticular and 22 erosive forms) and 20 patients with OSCC (6 in low stage and 14 in advanced stage) who were selected randomly. The study was conducted at the Cancer Department, Clinic of Oral Medicine, Tehran University of Medical Sciences. The serum and saliva MMP-13 were assayed by ELISA method. Statistical analysis of the Student's t-test, ANOVA and Pearson correlation coefficient was performed.
RESULTS
There were no significant differences in mean saliva and serum levels of MMP-13 between patients with OSCC and OLP and their subgroups. Serum MMP-13 correlated significantly with unstimulated (r = 0.307, p= 0.048), but not with stimulated, saliva MMP-13.
CONCLUSION
Serum and saliva MMP-13 levels appear to be statistically similar in OLP and OSCC.
背景
口腔扁平苔藓（OLP）已被归类为一种癌前病变。基质金属蛋白酶-13（MMP-13）或胶原酶-3可能在癌症发展中起关键作用。本研究的目的是比较口腔扁平苔藓（OLP）患者和口腔鳞状细胞癌（OSCC）患者血清和唾液中的MMP-13水平。
方法
本横断面研究对随机选取的30例OLP患者（8例网状型和22例糜烂型）和20例OSCC患者（6例低分期和14例高分期）进行。研究在德黑兰医科大学口腔医学诊所肿瘤科进行。采用ELISA法检测血清和唾液中的MMP-13。进行了学生t检验、方差分析和Pearson相关系数的统计分析。
结果
OSCC患者和OLP患者及其亚组之间，唾液和血清中MMP-13的平均水平无显著差异。血清MMP-13与未刺激唾液中的MMP-13显著相关（r = 0.307，p = 0.048），但与刺激唾液中的MMP-13无显著相关性。
结论
OLP和OSCC患者血清和唾液中MMP-13水平在统计学上似乎相似。
Zotero 插件