Lee Chang-Hoon, Kim Jimin, Jang Eun Jin, Kim Yun Jung, Choi Seongmi, Lee Joon-Ho, Kim Deog Kyeom, Yim Jae-Joon, Yoon Ho Il
Division for Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Republic of Korea, Seoul, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Division for Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Republic of Korea, Seoul, Republic of Korea.
BMJ Open. 2015 Nov 6;5(11):e008416. doi: 10.1136/bmjopen-2015-008416.
Few nationwide population-based studies have examined the burden of asthma during pregnancy. Here, we investigated the burden and medical treatment of asthma during pregnancy requiring healthcare utilisation in South Korea.
Cohort study.
Nationwide insurance claims database.
A total of 1,306,281 pregnant women who delivered in South Korea in 2009-2011.
The prevalence and exacerbation rates of asthma requiring healthcare utilisation, and the prescription of antiasthmatic drugs during pregnancy.
The prevalence of asthma requiring healthcare utilisation was 0.43% among pregnant women. Among those with asthma requiring healthcare utilisation, 6.9% were hospitalised and treated with systemic steroids and short-acting β2-agonists during pregnancy. Oral drugs were prescribed less during the third trimester than during the first trimester (all p values for trends were <0.001). A significant number of patients with asthma were likely to stop taking antiasthmatic drugs after becoming pregnant.
The prevalence of asthma requiring healthcare utilisation during pregnancy was not very high. However, a significant number of women were likely to stop taking antiasthmatic drugs, and those who did tended to experience exacerbations.
很少有基于全国人口的研究调查过孕期哮喘的负担。在此，我们调查了韩国孕期需要医疗服务利用的哮喘负担及药物治疗情况。
队列研究。
全国保险理赔数据库。
2009年至2011年在韩国分娩的总共1306281名孕妇。
需要医疗服务利用的哮喘患病率及加重率，以及孕期抗哮喘药物的处方情况。
孕妇中需要医疗服务利用的哮喘患病率为0.43%。在那些需要医疗服务利用的哮喘患者中，6.9%在孕期住院并接受全身用类固醇和短效β2受体激动剂治疗。孕晚期口服药物的处方量比孕早期少（所有趋势的p值均<0.001）。相当数量的哮喘患者在怀孕后可能会停止服用抗哮喘药物。
孕期需要医疗服务利用的哮喘患病率不是很高。然而，相当数量的女性可能会停止服用抗哮喘药物，而那些停药的女性往往会病情加重。
